Modern plant metabolomics: Advanced natural product gene discoveries, improved technologies, and future prospects

Sumner, Lloyd W.; Lei, Zhentian; Nikolau, Basil J.; Saito, Kazuki

doi:10.1039/c4np00072b

Title: Modern plant metabolomics: Advanced natural product gene discoveries, improved technologies, and future prospects

Journal Article · Fri Oct 24 00:00:00 EDT 2014 · Natural Product Reports

DOI:https://doi.org/10.1039/c4np00072b· OSTI ID:1227150

Sumner, Lloyd W. ^[1]; Lei, Zhentian ^[1]; Nikolau, Basil J. ^[2]; Saito, Kazuki ^[3]

The Samuel Roberts Noble Foundation, Ardmore, OK (United States)
Iowa State Univ., Ames, IA (United States); Ames Lab., Ames, IA (United States)
RIKEN Center for Sustainable Resource Science, Tsurumi-ku (Japan); Chiba Univ., Chuo-ku (Japan)

Plant metabolomics has matured and modern plant metabolomics has accelerated gene discoveries and the elucidation of a variety of plant natural product biosynthetic pathways. This study highlights specific examples of the discovery and characterization of novel genes and enzymes associated with the biosynthesis of natural products such as flavonoids, glucosinolates, terpenoids, and alkaloids. Additional examples of the integration of metabolomics with genome-based functional characterizations of plant natural products that are important to modern pharmaceutical technology are also reviewed. This article also provides a substantial review of recent technical advances in mass spectrometry imaging, nuclear magnetic resonance imaging, integrated LC-MS-SPE-NMR for metabolite identifications, and x-ray crystallography of microgram quantities for structural determinations. The review closes with a discussion on the future prospects of metabolomics related to crop species and herbal medicine.

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Research Organization:: Ames Laboratory (AMES), Ames, IA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-07CH11358

OSTI ID:: 1227150

Report Number(s):: IS-J-8609; NPRRDF

Journal Information:: Natural Product Reports, Vol. 32, Issue 2; ISSN 0265-0568

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 150 works

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