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Title: Compositions containing nucleosides and manganese and their uses

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
1226548
Report Number(s):
9,186,406
12/673,709
DOE Contract Number:
FG02-04ER63918
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Aug 18
Research Org:
The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc., Bethesda, MD (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES