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Title: Synthesis of [18F]arenes via the copper-mediated [18F]fluorination of boronic acids

Here, a copper-mediated radiofluorination of aryl- and vinylboronic acids with K18F is described. This method exhibits high functional group tolerance and is effective for the radiofluorination of a range of electron-deficient, -neutral, and -rich aryl-, heteroaryl-, and vinylboronic acids. This method has been applied to the synthesis of [18F]FPEB, a PET radiotracer for quantifying metabotropic glutamate 5 receptors.
Authors:
 [1] ;  [1] ;  [2] ;  [2] ;  [2] ;  [2] ;  [3]
  1. Univ. of Michigan Medical School, Ann Arbor, MI (United States)
  2. Univ. of Michigan, Ann Arbor, MI (United States)
  3. Univ. of Michigan Medical School, Ann Arbor, MI (United States); Univ. of Michigan, Ann Arbor, MI (United States)
Publication Date:
OSTI Identifier:
1225990
Grant/Contract Number:
SC0012484
Type:
Published Article
Journal Name:
Organic Letters
Additional Journal Information:
Journal Volume: 17; Journal Issue: 23; Journal ID: ISSN 1523-7060
Publisher:
American Chemical Society
Research Org:
Univ. of Michigan, Ann Arbor, MI (United States)
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY