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Title: Liquid chromatography detection unit, system, and method

Patent ·
OSTI ID:1224443

An embodiment of a liquid chromatography detection unit includes a fluid channel and a radiation detector. The radiation detector is operable to image a distribution of a radiolabeled compound as the distribution travels along the fluid channel. An embodiment of a liquid chromatography system includes an injector, a separation column, and a radiation detector. The injector is operable to inject a sample that includes a radiolabeled compound into a solvent stream. The position sensitive radiation detector is operable to image a distribution of the radiolabeled compound as the distribution travels along a fluid channel. An embodiment of a method of liquid chromatography includes injecting a sample that comprises radiolabeled compounds into a solvent. The radiolabeled compounds are then separated. A position sensitive radiation detector is employed to image distributions of the radiolabeled compounds as the radiolabeled compounds travel along a fluid channel.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
9,170,242
Application Number:
13/391,725
OSTI ID:
1224443
Resource Relation:
Patent File Date: 2010 Aug 24
Country of Publication:
United States
Language:
English

References (3)

System for Purification and Analysis of Radiochemical Products Yielded by Microfluidic Synthesis Devices patent-application March 2008
Sensitive measurement of positron emitters eluted from HPLC journal August 2001
Development of a High-Sensitivity Radiation Detector for Chromatography journal June 2011