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Title: Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs

This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
Authors:
; ; ; ; ; ; ; ; ; ;
Publication Date:
OSTI Identifier:
1223701
Report Number(s):
9,163,271
13/475,792
DOE Contract Number:
FG03-00ER45812
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 May 18
Research Org:
The Scripps Research Institute, La Jolla, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES