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Title: Over-expression of NADH-dependent oxidoreductase (fucO) for increasing furfural or 5-hydroxymethylfurfural tolerance

The subject invention pertains to the discovery that the NADH-dependent propanediol oxidoreductase (FucO) can reduce furfural. This allows for a new approach to improve furfural tolerance in bacterial and/or yeast cells used to produce desired products. Thus, novel biocatalysts (bacterial, fungal or yeast cells) exhibiting increased tolerance to furfural and 5-hydroxymethylfurfural (5-HMF) are provided as are methods of making and using such biocatalysts for the production of a desired product.
Authors:
; ; ; ; ;
Publication Date:
OSTI Identifier:
1223111
Report Number(s):
9,157,102
14/008,015
DOE Contract Number:
FG36-08GO88142
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Mar 29
Research Org:
University of Florida Research Foundation, Inc., Gainesville, FL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES