skip to main content

Title: Total cyanide mass measurement with micro-ion selective electrode for determination of specific activity of carbon-11 cyanide

In this study, we aim to directly measure the specific activity (SA) of the carbon-11 cyanide ([ 11C]CN¯) produced by our in-house built automated [ 11C]HCN production system and to identify the major sources of 12C-cyanide ( 12CN¯). The [ 11C]CN¯ is produced from [ 11C]CO 2, which is generated by the 14N(p,α) 11C nuclear reaction using a cyclotron. Direct measurement of cyanide concentrations was accomplished using a relatively inexpensive, and easy to use ion selective electrode (ISE) which offered an appropriate range of sensitivity for detecting mass. Multiple components of the [ 11C]HCN production system were isolated in order to determine their relative contributions to 12CN¯ mass. It was determined that the system gases were responsible for approximately 30% of the mass, and that the molecular sieve/nickel furnace unit contributed approximately 70% of the mass. Beam on target (33 µA for 1 and 10 min) did not contribute significantly to the mass. Additionally, we compared the SA of our [ 11C]HCN precursor determined using the ISE to the SA of our current [ 11C]CN¯ derived radiotracers determined by HPLC to assure there was no significant difference between the two methods. These results are the first reported use of anmore » ion selective electrode to determine the SA of no-carrier-added cyanide ion, and clearly show that it is a valuable, inexpensive and readily available tool suitable for this purpose.« less
 [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1]
  1. Brookhaven National Lab. (BNL), Upton, NY (United States)
Publication Date:
OSTI Identifier:
Report Number(s):
Journal ID: ISSN 0969-8043; R&D Project: 06218; KP1602010
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Applied Radiation and Isotopes
Additional Journal Information:
Journal Volume: 102; Journal Issue: C; Journal ID: ISSN 0969-8043
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
Country of Publication:
United States
42 ENGINEERING; carbon-11 cyanide; automated [11C]HCN production system; micro ion selective electrode; specific activity