Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model

Dash, Satyakam; Mueller, Thomas J.; Venkataramanan, Keerthi P.; Papoutsakis, Eleftherios T.; Maranas, Costas D.

doi:10.1186/s13068-014-0144-4

Title: Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model

Journal Article · Tue Oct 14 00:00:00 EDT 2014 · Biotechnology for Biofuels

DOI:https://doi.org/10.1186/s13068-014-0144-4· OSTI ID:1221631

Dash, Satyakam ^[1]; Mueller, Thomas J. ^[1]; Venkataramanan, Keerthi P. ^[2]; Papoutsakis, Eleftherios T. ^[2]; Maranas, Costas D. ^[1]

Pennsylvania State Univ., University Park, PA (United States)
Delaware Biotechnology Institute, Newark, DE (United States); Univ. of Delaware, Newark, DE (United States)

Clostridia are anaerobic Gram-positive Firmicutes containing broad and flexible systems for substrate utilization, which have been used successfully to produce a range of industrial compounds. In particular, Clostridium acetobutylicum has been used to produce butanol on an industrial scale through acetone-butanol-ethanol (ABE) fermentation. A genome-scale metabolic (GSM) model is a powerful tool for understanding the metabolic capacities of an organism and developing metabolic engineering strategies for strain development. The integration of stress-related specific transcriptomics information with the GSM model provides opportunities for elucidating the focal points of regulation.

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Research Organization:: Pennsylvania State Univ., University Park, PA (United States); Univ. of Delaware, Newark, DE (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0007092; sc0007092

OSTI ID:: 1221631

Alternate ID(s):: OSTI ID: 1454689

Journal Information:: Biotechnology for Biofuels, Vol. 7, Issue 1; ISSN 1754-6834

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 43 works

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
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genome-scale metabolic model

Title: Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model

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