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Title: Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model

Clostridia are anaerobic Gram-positive Firmicutes containing broad and flexible systems for substrate utilization, which have been used successfully to produce a range of industrial compounds. Clostridium acetobutylicum has been used to produce butanol on an industrial scale through acetone-butanol-ethanol (ABE) fermentation. A genome-scale metabolic (GSM) model is a powerful tool for understanding the metabolic capacities of an organism and developing metabolic engineering strategies for strain development. The integration of stress related specific transcriptomics information with the GSM model provides opportunities for elucidating the focal points of regulation.
 [1] ;  [1] ;  [2] ;  [2] ;  [1]
  1. Pennsylvania State Univ., University Park, PA (United States)
  2. Delaware Biotechnology Institute, Newark, DE (United States); Univ. of Delaware, Newark, DE (United States)
Publication Date:
OSTI Identifier:
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Biotechnology for Biofuels
Additional Journal Information:
Journal Volume: 7; Journal Issue: 1; Journal ID: ISSN 1754-6834
BioMed Central
Research Org:
Pennsylvania State Univ., University Park, PA (United States)
Sponsoring Org:
Country of Publication:
United States
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; Clostridium acetobutylicum; CoreReg; regulation; genome-scale metabolic model