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Title: An open-source computational and data resource to analyze digital maps of immunopeptidomes

We present a novel proteomics-based workflow and an open source data and computational resource for reproducibly identifying and quantifying HLA-associated peptides at high-throughput. The provided resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra and the analysis of quantitative digital maps of HLA peptidomes generated by SWATH mass spectrometry (MS). This is the first community-based study towards the development of a robust platform for the reproducible and quantitative measurement of HLA peptidomes, an essential step towards the design of efficient immunotherapies.
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Publication Date:
OSTI Identifier:
Report Number(s):
48680; 400412000
DOE Contract Number:
Resource Type:
Journal Article
Resource Relation:
Journal Name: eLife, 4:Article No. e07661
Research Org:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org:
Country of Publication:
United States
human leukocytes antigen / immunopeptidome / targeted / SWATH-MS / DIA; Environmental Molecular Sciences Laboratory