Fluorescence dye tagging scheme for mercury quantification and speciation

Jiao, Hong; Catterall, Hannah

Title: Fluorescence dye tagging scheme for mercury quantification and speciation

Patent · Tue Sep 22 00:00:00 EDT 2015

OSTI ID:1221386

Jiao, Hong; Catterall, Hannah

A fluorescent dye or fluorophore capable of forming complexes with mercury comprises 6,8-difluoro-7-hydroxy-2-oxo-2H-chromene-3-carboxylate amide, wherein the amide is formed by reacting the succinimidyl ester (Pacific Blue.TM.) with an amino acid containing a thiol group, such as cysteine or glutathione. Mercury complexes of the fluorophore fluoresce when excited by a UV or violet laser diode, and the detected intensity can be calibrated to quantify the concentration of mercury in a sample reacted with the fluorophore.

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Research Organization:: Los Gatos Research, Mountain View, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: SC0004430

Assignee:: Los Gatos Research (Mountain View, CA)

Patent Number(s):: 9,139,550

Application Number:: 13/570,548

OSTI ID:: 1221386

Resource Relation:: Patent File Date: 2012 Aug 09

Country of Publication:: United States

Language:: English

References (7)

Mercury determination Green, Gary L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5733786 US Patent Document 5,733,786	patent	March 1998
Molecular fluorescence sensor for highly sensitive and selective detection of mercury Zang, Ling; Che, Yanke https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8058075 US Patent Document 8,058,075	patent	November 2011
Fluorescent sensor for mercury Wang, Zidong; Lee, Jung Heon; Lu, Yi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8062893 US Patent Document 8,062,893	patent	November 2011
Violet laser excitable dyes and their method of use Buller, Gayle; Liu, Jixiang; Yue, Stephen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8158801 US Patent Document 8,158,801	patent	April 2012
Enhanced Amine and Amino Acid Analysis Using Pacific Blue and the Mars Organic Analyzer Microchip Capillary Electrophoresis System Chiesl, Thomas N.; Chu, Wai K.; Stockton, Amanda M. Analytical Chemistry, Vol. 81, Issue 7 https://doi.org/10.1021/ac8023334	journal	April 2009
Capillary Electrophoresis Analysis of Organic Amines and Amino Acids in Saline and Acidic Samples Using the Mars Organic Analyzer Stockton, Amanda M.; Chiesl, Thomas N.; Lowenstein, Tim K. Astrobiology, Vol. 9, Issue 9 https://doi.org/10.1089/ast.2009.0357	journal	November 2009
Toward Total Automation of Microfluidics for Extraterrestial In Situ Analysis Mora, Maria F.; Greer, Frank; Stockton, Amanda M. Analytical Chemistry, Vol. 83, Issue 22 https://doi.org/10.1021/ac202095k	journal	November 2011

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