Insulin-Degrading Enzyme: Structure-Function Relationship and its Possible Roles in Health and Disease
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November 2009 |
The insulysin (insulin degrading enzyme) enigma
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September 2006 |
Alzheimer's β-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
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May 1994 |
Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme
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January 2010 |
Endosomal Proteolysis of Glucagon at Neutral pH Generates the Bioactive Degradation Product Miniglucagon-(19–29)
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December 2003 |
An Insulin-Degrading Enzyme Inhibitor Decreases Amylin Degradation, Increases Amylin-Induced Cytotoxicity, and Increases Amyloid Formation in Insulinoma Cell Cultures
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August 2003 |
Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity
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February 2009 |
Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme
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May 1998 |
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism
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October 2006 |
Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin
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May 2008 |
Functional Relevance of a Novel SlyX Motif in Non-conventional Secretion of Insulin-degrading Enzyme
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May 2011 |
Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme
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June 2003 |
Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts
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October 2008 |
Deletion of the Fission Yeast Homologue of Human Insulinase Reveals a TORC1-Dependent Pathway Mediating Resistance to Proteotoxic Stress
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June 2013 |
Proteolytically Inactive Insulin-Degrading Enzyme Inhibits Amyloid Formation Yielding Non-Neurotoxic Aβ Peptide Aggregates
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April 2013 |
Effect of Insulinase-Inhibitor on Hypoglycemic Action of Insulin
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September 1955 |
Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
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January 1996 |
Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats
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September 2000 |
Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein
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April 2004 |
Insulin-degrading enzyme regulates the levels of insulin, amyloid -protein, and the -amyloid precursor protein intracellular domain in vivo
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March 2003 |
Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance
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June 2011 |
Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin
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May 2010 |
Optimization of Peptide Hydroxamate Inhibitors of Insulin-Degrading Enzyme Reveals Marked Substrate-Selectivity
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March 2013 |
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones
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May 2014 |
Kinetic target-guided synthesis
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January 2010 |
Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks
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March 2002 |
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
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October 2004 |
In Situ Click Chemistry: Enzyme-Generated Inhibitors of Carbonic Anhydrase II
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December 2004 |
Inhibitors of HIV-1 Protease by Using In Situ Click Chemistry
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February 2006 |
Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry
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March 2009 |
Exploring Drug Target Flexibility Using in Situ Click Chemistry: Application to a Mycobacterial Transcriptional Regulator
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August 2010 |
Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis
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May 2014 |
Absolute Potassium Cation Affinities (PCAs) in the Gas Phase
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July 2003 |
1,2,5-, 1,3,4- and 1,2,4-Oxadiazoles: A theoretical study of electric dipole moments
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January 1968 |
Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme
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August 2013 |
Hydroxamates: Relationships between Structure and Plasma Stability
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November 2009 |
Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation
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December 1998 |
Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)
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January 2002 |
Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme
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March 2009 |
[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |
The CCP 4 molecular-graphics project
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October 2002 |
Coot model-building tools for molecular graphics
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November 2004 |
Determination of the regularization parameter in indirect-transform methods using perceptual criteria
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August 1992 |
CRYSOL – a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates
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December 1995 |