Extracellular dopamine and its metabolites in the nucleus accumbens of Fisher and Lewis rats: Basal levels and cocaine-induced changes
- State Univ. of New York, Stony Brook, NY (United States)
- Brookhaven National Lab., Upton, NY (United States)
Rats of the Lewis (LEW) strain show a greater preference for drugs of abuse than do Fisher 344 (F344) rats. The in vivo microdialysis procedure was used to examine basal and cocaine-evoked extracellular (EC) levels of dopamine (DA), DOPAC, and HVA in the nucleus accumbens (NAc) of F344 and LEW rats. The basal EC levels of the DA metabolites DOPAC and HVA in the NAc were markedly lower in LEW than in F344 rats. Although the increase in ECDA after 3, 10 or 30 mg/kg, i/p. of cocaine was similar in both strains, LEW rats had a smaller peak DA elevation followed by a slower return to basal DA levels at the 30 mg/kg dose. The neurochemical differences observed may contribute to the strain differences in the behavioral response to cocaine. 20 refs., 3 figs.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 121310
- Journal Information:
- Life Sciences, Vol. 56, Issue 6; Other Information: PBD: 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of ionizing radiation on in vivo striatal release of dopamine in the rat
Chronic cocaine administration induces opposite changes in dopamine receptors in the striatum and nucleus accumbens