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Title: Orthogonal translation components for the in vivo incorporation of unnatural amino acids

The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
Authors:
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Publication Date:
OSTI Identifier:
1209477
Report Number(s):
9,102,932
13/492,296
DOE Contract Number:
FG03-00ER45601
Resource Type:
Patent
Research Org:
The Scripps Research Institute, La Jolla, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES