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Title: Mass spectrometry for biomarker development

Biomarkers potentially play a crucial role in early disease diagnosis, prognosis and targeted therapy. In the past decade, mass spectrometry based proteomics has become increasingly important in biomarker development due to large advances in technology and associated methods. This chapter mainly focuses on the application of broad (e.g. shotgun) proteomics in biomarker discovery and the utility of targeted proteomics in biomarker verification and validation. A range of mass spectrometry methodologies are discussed emphasizing their efficacy in the different stages in biomarker development, with a particular emphasis on blood biomarker development.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
1203908
Report Number(s):
PNNL-SA-97608
Journal ID: ISSN 2451--9766; 46206; 400412000
DOE Contract Number:
AC05-76RL01830
Resource Type:
Book
Resource Relation:
Related Information: General Methods in Biomarker Research and their Applications. Biomarkers in Disease: Methods, Discoveries and Applications, 17-48
Publisher:
V Preedy and V Patel; Springer, Heidelberg , Germany.
Research Org:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
Biomarker, proteomics, mass spectrometry, shotgun proteomics, targeted proteomics, SRM, MRM, plasma, serum; Environmental Molecular Sciences Laboratory