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Title: Surfactant-free Gd3+-ion-containing carbon nanotube MRI contrast agents for stem cell labeling

Journal Article · · Nanoscale
DOI:https://doi.org/10.1039/c5nr02078f· OSTI ID:1203741
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  1. Rice Univ., Houston, TX (United States)
  2. St. Luke's Episcopal Hospital, Houston, TX (United States)
  3. Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
  4. Univ. of Virginia, Charlottesville, VA (United States)
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There is an ever increasing interest in developing new stem cell therapies. However, imaging and tracking stem cells in vivo after transplantation remains a serious challenge. In this work, we report new, functionalized and high-performance Gd3+-ion-containing ultra-short carbon nanotube (US-tube) MRI contrast agent (CA) materials which are highly-water-dispersible (ca. 35 mg ml–1) without the need of a surfactant. The new materials have extremely high T1-weighted relaxivities of 90 (mM s)–1 per Gd3+ ion at 1.5 T at room temperature and have been used to safely label porcine bone-marrow-derived mesenchymal stem cells for MR imaging. The labeled cells display excellent image contrast in phantom imaging experiments, and TEM images of the labeled cells, in general, reveal small clusters of the CA material located within the cytoplasm with 109 Gd3+ ions per cell.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
The Welch Foundation; National Science Foundation (NSF); E.I. DuPont de Nemours & Co.; Dow Chemical Company; State of Illinois; USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1203741
Journal Information:
Nanoscale, Vol. 7, Issue 28; ISSN 2040-3364
Publisher:
Royal Society of ChemistryCopyright Statement
Country of Publication:
United States
Language:
ENGLISH
Citation Metrics:
Cited by: 20 works
Citation information provided by
Web of Science

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Cited By (4)

Stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance T 1 magnetic resonance imaging contrast agents journal January 2018
A New High-Performance Gadonanotube-Polymer Hybrid Material for Stem Cell Labeling and Tracking by MRI journal July 2018
Labeling Stem Cells with a New Hybrid Bismuth/Carbon Nanotube Contrast Agent for X-Ray Imaging journal June 2019
Multiwalled carbon nanotube hybrids as MRI contrast agents journal January 2016

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