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Title: Helium-3 and helium-4 acceleration by high power laser pulses for hadron therapy

The laser driven acceleration of ions is considered a promising candidate for an ion source for hadron therapy of oncological diseases. Though proton and carbon ion sources are conventionally used for therapy, other light ions can also be utilized. Whereas carbon ions require 400 MeV per nucleon to reach the same penetration depth as 250 MeV protons, helium ions require only 250 MeV per nucleon, which is the lowest energy per nucleon among the light ions (heavier than protons). This fact along with the larger biological damage to cancer cells achieved by helium ions, than that by protons, makes this species an interesting candidate for the laser driven ion source. Two mechanisms (magnetic vortex acceleration and hole-boring radiation pressure acceleration) of PW-class laser driven ion acceleration from liquid and gaseous helium targets are studied with the goal of producing 250 MeV per nucleon helium ion beams that meet the hadron therapy requirements. We show that He3 ions, having almost the same penetration depth as He4 with the same energy per nucleon, require less laser power to be accelerated to the required energy for the hadron therapy.
Authors:
 [1] ;  [2] ;  [2] ;  [3] ;  [4] ;  [5] ;  [5] ;  [6]
  1. Univ. of California, Berkeley, CA (United States)
  2. Lawrence Berkeley National Lab., CA (United States)
  3. Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab., CA (United States)
  4. Kansai Photon Science Institute, JAEA, Kyoto (Japan)
  5. Institute of Physics ASCR, v.v.i. (FZU), ELI-Beamlines Project, Prague (Czech Republic)
  6. Heidelberger Ionenstrahl0Therapie Centrum (HIT), Heidelberg (Germany)
Publication Date:
OSTI Identifier:
1188514
Report Number(s):
LBNL-186519
Journal ID: ISSN 1098-4402; PRABFM; CZ.1.05/1.1.00/02.0061
Grant/Contract Number:
AC02-05CH11231; FG02-12ER41798; AC02- 05CH11231
Type:
Published Article
Journal Name:
Physical Review Special Topics. Accelerators and Beams
Additional Journal Information:
Journal Volume: 18; Journal Issue: 6; Journal ID: ISSN 1098-4402
Publisher:
American Physical Society (APS)
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Accelerator & Fusion Research Division
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; 62 RADIOLOGY AND NUCLEAR MEDICINE