Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy

Rojas, J. V.; Woodward, J. D.; Chen, N.; Rondinone, A. J.; Castano, C. H.; Mirzadeh, S.

doi:10.1016/j.nucmedbio.2015.03.007

Title: Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for ²²³Ra and ²²⁵Ra for targeted alpha therapy

Journal Article · Thu Mar 19 00:00:00 EDT 2015 · Nuclear Medicine and Biology

DOI:https://doi.org/10.1016/j.nucmedbio.2015.03.007· OSTI ID:1185834

Rojas, J. V. ^[1]; Woodward, J. D. ^[2]; Chen, N. ^[3]; Rondinone, A. J. ^[2]; Castano, C. H. ^[4];

^[2]

Missouri Univ. of Science and Technology, Rolla, MO (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Provision Center for Biomedical Research, Knoxville, TN (United States)
Missouri Univ. of Science and Technology, Rolla, MO (United States)

We present that targeted alpha therapy (TAT) has the potential for killing micro-metastases with minimum collateral damage to surrounding healthy tissue. In-vivo generator radionuclides, such as ²²³Ra, ²²⁵Ra, and ²²⁵Ac, are of special interest for radiotherapeutic applications as they emit multiple α-particles during their decay. Utilizing appropriate carriers capable of retaining both the parent radioisotope as well as daughter products is important for the effective delivery of the radioisotope to the tumor site while mitigating global in vivo radiotoxicity. In this article, LaPO₄ core and core + 2 shells nanoparticles (NPs) (NPs with 2 layers of cold LaPO₄ deposited on the core surfaces) were synthesized containing either ²²³Ra or ²²⁵Ra/²²⁵Ac, and the retention of the parents and daughters within the NPs in vitro was investigated.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1185834

Alternate ID(s):: OSTI ID: 1327625; OSTI ID: 1359708

Journal Information:: Nuclear Medicine and Biology, Vol. 42, Issue 7; ISSN 0969-8051

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 42 works

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Ra-224 labeling of calcium carbonate microparticles for internal α-therapy: Preparation, stability, and biodistribution in mice Westrøm, Sara; Malenge, Marion; Jorstad, Ida Sofie Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 61, Issue 6 https://doi.org/10.1002/jlcr.3610	journal	March 2018
Functionalized TiO2 nanoparticles labelled with 225Ac for targeted alpha radionuclide therapy Cędrowska, Edyta; Pruszynski, Marek; Majkowska-Pilip, Agnieszka Journal of Nanoparticle Research, Vol. 20, Issue 3 https://doi.org/10.1007/s11051-018-4181-y	journal	March 2018
Gadolinium vanadate nanocrystals as carriers of α-emitters ( ²²⁵ Ac, ²²⁷ Th) and contrast agents Toro-González, Miguel; Dame, Ashley N.; Mirzadeh, Saed Journal of Applied Physics, Vol. 125, Issue 21 https://doi.org/10.1063/1.5096880	journal	June 2019
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Title: Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy

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Title: Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for ²²³Ra and ²²⁵Ra for targeted alpha therapy