Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections

Kertesz, Vilmos; Paranthaman, Nithya; Moench, Paul; Catoire, Alexandre; Flarakos, Jimmy; Van Berkel, Gary J.

doi:10.4155/bio.14.130

Title: Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections

Journal Article · Wed Oct 01 00:00:00 EDT 2014 · Bioanalysis

DOI:https://doi.org/10.4155/bio.14.130· OSTI ID:1185413

Kertesz, Vilmos ^[1]; Paranthaman, Nithya ^[2]; Moench, Paul ^[3]; Catoire, Alexandre ^[3]; Flarakos, Jimmy ^[3]; Van Berkel, Gary J. ^[1]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Organic and Biological Mass Spectrometry Group. Chemical Sciences Division
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Organic and Biological Mass Spectrometry Group. Chemical Sciences Division; Georgia Inst. of Technology, Atlanta, GA (United States). ORISE HERE Intern
Novartis Inst. for Biomedical Research (NIBR), East Hanover, NJ (United States)

The aim of this paper was to evaluate the analytical performance of a fully automated droplet-based surface-sampling system for determining the distribution of the drugs acetaminophen and terfenadine, and their metabolites, in rat thin tissue sections. The following are the results: The rank order of acetaminophen concentration observed in tissues was stomach > small intestine > liver, while the concentrations of its glucuronide and sulfate metabolites were greatest in the liver and small intestine. Terfenadine was most concentrated in the liver and kidney, while its major metabolite, fexofenadine, was found in the liver and small intestine. In conclusion, the spatial distributions of both drugs and their respective metabolites observed in this work were consistent with previous studies using radiolabeled drugs.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE; AB Sciex, Framingham, MA (United States); Novartis Inst. for BioMedical Research (NIBR), Inc., Cambridge, MA (United States)

Grant/Contract Number:: AC05-00OR22725; NFE-10-02966

OSTI ID:: 1185413

Journal Information:: Bioanalysis, Vol. 6, Issue 19; ISSN 1757-6180

Publisher:: Future Science GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 15 works

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59 BASIC BIOLOGICAL SCIENCES
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liquid microjunction
droplet-based liquid extraction
autosampler
drug discovery
spatial distribution

Title: Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections

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