Viral Receptor-Binding Site Antibodies with Diverse Germline Origins

Schmidt, Aaron G.; Therkelsen, Matthew D.; Stewart, Shaun; Kepler, Thomas B.; Liao, Hua-Xin; Moody, M. Anthony; Haynes, Barton F.; Harrison, Stephen C.

doi:10.1016/j.cell.2015.04.028

Title: Viral Receptor-Binding Site Antibodies with Diverse Germline Origins

Journal Article · Wed Jun 15 00:00:00 EDT 2016 · Cell

DOI:https://doi.org/10.1016/j.cell.2015.04.028· OSTI ID:1183602

Schmidt, Aaron G.; Therkelsen, Matthew D.; Stewart, Shaun; Kepler, Thomas B.; Liao, Hua-Xin; Moody, M. Anthony; Haynes, Barton F.; Harrison, Stephen C. ^[1]

Novartis

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: NIHHHMI

OSTI ID:: 1183602

Journal Information:: Cell, Vol. 161, Issue (5) ; 05, 2015

Country of Publication:: United States

Language:: ENGLISH

Citation Metrics:

Cited by: 114 works

Citation information provided by
Web of Science

References (40)

Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses Burton, D. R.; Poignard, P.; Stanfield, R. L. Science, Vol. 337, Issue 6091 https://doi.org/10.1126/science.1225416	journal	July 2012
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Broadly Neutralizing Antiviral Antibodies Corti, Davide; Lanzavecchia, Antonio Annual Review of Immunology, Vol. 31, Issue 1 https://doi.org/10.1146/annurev-immunol-032712-095916	journal	March 2013
A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins Corti, D.; Voss, J.; Gamblin, S. J. Science, Vol. 333, Issue 6044 https://doi.org/10.1126/science.1205669	journal	July 2011
Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans New England Journal of Medicine, Vol. 360, Issue 25, p. 2605-2615 https://doi.org/10.1056/NEJMoa0903810	journal	June 2009
Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo DiLillo, David J.; Tan, Gene S.; Palese, Peter Nature Medicine, Vol. 20, Issue 2 https://doi.org/10.1038/nm.3443	journal	January 2014
Antibody Recognition of a Highly Conserved Influenza Virus Epitope Ekiert, D. C.; Bhabha, G.; Elsliger, M. -A. Science, Vol. 324, Issue 5924 https://doi.org/10.1126/science.1171491	journal	April 2009
Cross-neutralization of influenza A viruses mediated by a single antibody loop Ekiert, Damian C.; Kashyap, Arun K.; Steel, John Nature, Vol. 489, Issue 7417 https://doi.org/10.1038/nature11414	journal	September 2012
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes Hai, R.; Krammer, F.; Tan, G. S. Journal of Virology, Vol. 86, Issue 10 https://doi.org/10.1128/JVI.00137-12	journal	March 2012
Viral membrane fusion Harrison, Stephen C. Nature Structural & Molecular Biology, Vol. 15, Issue 7 https://doi.org/10.1038/nsmb.1456	journal	July 2008
B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study Haynes, Barton F.; Kelsoe, Garnett; Harrison, Stephen C. Nature Biotechnology, Vol. 30, Issue 5 https://doi.org/10.1038/nbt.2197	journal	May 2012
Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site Hong, M.; Lee, P. S.; Hoffman, R. M. B. Journal of Virology, Vol. 87, Issue 22 https://doi.org/10.1128/JVI.01388-13	journal	September 2013
Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization Klein, Florian; Diskin, Ron; Scheid, Johannes F. Cell, Vol. 153, Issue 1 https://doi.org/10.1016/j.cell.2013.03.018	journal	March 2013
Mechanism of Neutralization of Influenza Virus Infectivity by Antibodies Knossow, M.; Gaudier, M.; Douglas, A. Virology, Vol. 302, Issue 2 https://doi.org/10.1006/viro.2002.1625	journal	October 2002
A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin Krause, J. C.; Tsibane, T.; Tumpey, T. M. Journal of Virology, Vol. 85, Issue 20 https://doi.org/10.1128/JVI.00700-11	journal	August 2011
Inference of Macromolecular Assemblies from Crystalline State Krissinel, Evgeny; Henrick, Kim Journal of Molecular Biology, Vol. 372, Issue 3 https://doi.org/10.1016/j.jmb.2007.05.022	journal	September 2007
High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies Liao, Hua-Xin; Levesque, Marc C.; Nagel, Ashleigh Journal of Virological Methods, Vol. 158, Issue 1-2 https://doi.org/10.1016/j.jviromet.2009.02.014	journal	June 2009
HIV-1 neutralizing antibodies: understanding nature's pathways Mascola, John R.; Haynes, Barton F. Immunological Reviews, Vol. 254, Issue 1 https://doi.org/10.1111/imr.12075	journal	June 2013
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded Anti-Hemagglutinin Antibodies Than Influenza Vaccination Moody, M. Anthony; Zhang, Ruijun; Walter, Emmanuel B. PLoS ONE, Vol. 6, Issue 10 https://doi.org/10.1371/journal.pone.0025797	journal	October 2011
Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified into three groups with distinct strain specificity: 1968–1973, 1977–1993 and 1997–2003 Okada, Jun; Ohshima, Nobuko; Kubota-Koketsu, Ritsuko Virology, Vol. 397, Issue 2 https://doi.org/10.1016/j.virol.2009.11.025	journal	February 2010
Localization of epitopes recognized by monoclonal antibodies that neutralized the H3N2 influenza viruses in man Okada, J.; Ohshima, N.; Kubota-Koketsu, R. Journal of General Virology, Vol. 92, Issue 2 https://doi.org/10.1099/vir.0.026419-0	journal	November 2010
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding Scheid, J. F.; Mouquet, H.; Ueberheide, B. Science, Vol. 333, Issue 6049 https://doi.org/10.1126/science.1207227	journal	July 2011
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody Schmidt, A. G.; Xu, H.; Khan, A. R. Proceedings of the National Academy of Sciences, Vol. 110, Issue 1 https://doi.org/10.1073/pnas.1218256109	journal	November 2012
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin Skehel, John J.; Wiley, Don C. Annual Review of Biochemistry, Vol. 69, Issue 1 https://doi.org/10.1146/annurev.biochem.69.1.531	journal	June 2000
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses Sui, Jianhua; Hwang, William C.; Perez, Sandra Nature Structural & Molecular Biology, Vol. 16, Issue 3 https://doi.org/10.1038/nsmb.1566	journal	February 2009
Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard Terwilliger, Thomas C.; Grosse-Kunstleve, Ralf W.; Afonine, Pavel V. Acta Crystallographica Section D Biological Crystallography, Vol. 64, Issue 1 https://doi.org/10.1107/S090744490705024X	journal	December 2007
Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia Tomaras, G. D.; Yates, N. L.; Liu, P. Journal of Virology, Vol. 82, Issue 24, p. 12449-12463 https://doi.org/10.1128/JVI.01708-08	journal	October 2008
Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid Weis, W.; Brown, J. H.; Cusack, S. Nature, Vol. 333, Issue 6172 https://doi.org/10.1038/333426a0	journal	June 1988
Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy West, Anthony P.; Scharf, Louise; Scheid, Johannes F. Cell, Vol. 156, Issue 4 https://doi.org/10.1016/j.cell.2014.01.052	journal	February 2014
Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin Whittle, J. R. R.; Zhang, R.; Khurana, S. Proceedings of the National Academy of Sciences, Vol. 108, Issue 34 https://doi.org/10.1073/pnas.1111497108	journal	August 2011
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation Wiley, D. C.; Wilson, I. A.; Skehel, J. J. Nature, Vol. 289, Issue 5796 https://doi.org/10.1038/289373a0	journal	January 1981
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1 Wu, X.; Yang, Z. -Y.; Li, Y. Science, Vol. 329, Issue 5993 https://doi.org/10.1126/science.1187659	journal	July 2010
A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin Xu, Rui; Krause, Jens C.; McBride, Ryan Nature Structural & Molecular Biology, Vol. 20, Issue 3 https://doi.org/10.1038/nsmb.2500	journal	February 2013
Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage: Key Mutations in Antibody Affinity Maturation Xu, Huafeng; Schmidt, Aaron G.; O'Donnell, Timothy Proteins: Structure, Function, and Bioinformatics, Vol. 83, Issue 4 https://doi.org/10.1002/prot.24745	journal	February 2015
Viral membrane fusion Harrison, Stephen C. Virology, Vol. 479-480 https://doi.org/10.1016/j.virol.2015.03.043	journal	May 2015
Host versus flu: antibodies win a round? Brooke, Christopher B.; Yewdell, Jonathan W. Nature Structural & Molecular Biology, Vol. 20, Issue 3 https://doi.org/10.1038/nsmb.2524	journal	March 2013
Taking Care of Unfinished Business and the Business of the 21st Century Stanfield, John H. American Behavioral Scientist, Vol. 56, Issue 10 https://doi.org/10.1177/0002764212454426	journal	August 2012

Cited By (37)

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site Strauch, Eva-Maria; Bernard, Steffen M.; La, David Nature Biotechnology, Vol. 35, Issue 7 https://doi.org/10.1038/nbt.3907	journal	June 2017
Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire Yeung, Yik Andy; Foletti, Davide; Deng, Xiaodi Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms13376	journal	November 2016
Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain Raymond, Donald D.; Stewart, Shaun M.; Lee, Jiwon Nature Medicine, Vol. 22, Issue 12 https://doi.org/10.1038/nm.4223	journal	November 2016
Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination Lee, Jiwon; Boutz, Daniel R.; Chromikova, Veronika Nature Medicine, Vol. 22, Issue 12 https://doi.org/10.1038/nm.4224	journal	November 2016
Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus Wen, Xiaolin; Mousa, Jarrod J.; Bates, John T. Nature Microbiology, Vol. 2, Issue 4 https://doi.org/10.1038/nmicrobiol.2016.272	journal	January 2017
How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin Doud, Michael B.; Lee, Juhye M.; Bloom, Jesse D. Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-03665-3	journal	April 2018
Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses Clark, Lars E.; Mahmutovic, Selma; Raymond, Donald D. Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04271-z	journal	May 2018
Antibody responses to viral infections: a structural perspective across three different enveloped viruses Murin, Charles D.; Wilson, Ian A.; Ward, Andrew B. Nature Microbiology, Vol. 4, Issue 5 https://doi.org/10.1038/s41564-019-0392-y	journal	March 2019
Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP Urusova, Darya; Carias, Lenore; Huang, Yining Nature Microbiology, Vol. 4, Issue 9 https://doi.org/10.1038/s41564-019-0461-2	journal	May 2019
Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses Kanekiyo, Masaru; Joyce, M. Gordon; Gillespie, Rebecca A. Nature Immunology, Vol. 20, Issue 3 https://doi.org/10.1038/s41590-018-0305-x	journal	February 2019
Current and future influenza vaccines Yamayoshi, Seiya; Kawaoka, Yoshihiro Nature Medicine, Vol. 25, Issue 2 https://doi.org/10.1038/s41591-018-0340-z	journal	January 2019
Structural insights into the design of novel anti-influenza therapies Wu, Nicholas C.; Wilson, Ian A. Nature Structural & Molecular Biology, Vol. 25, Issue 2 https://doi.org/10.1038/s41594-018-0025-9	journal	February 2018
Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies Bajic, Goran; van der Poel, Cees E.; Kuraoka, Masayuki Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-40175-8	journal	March 2019
Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody Raymond, Donald D.; Bajic, Goran; Ferdman, Jack Proceedings of the National Academy of Sciences, Vol. 115, Issue 1 https://doi.org/10.1073/pnas.1715471115	journal	December 2017
Affinity maturation in a human humoral response to influenza hemagglutinin McCarthy, Kevin R.; Raymond, Donald D.; Do, Khoi T. Proceedings of the National Academy of Sciences, Vol. 116, Issue 52 https://doi.org/10.1073/pnas.1915620116	journal	December 2019
Immunodominance and Antigenic Variation of Influenza Virus Hemagglutinin: Implications for Design of Universal Vaccine Immunogens Zost, Seth J.; Wu, Nicholas C.; Hensley, Scott E. The Journal of Infectious Diseases, Vol. 219, Issue Supplement_1 https://doi.org/10.1093/infdis/jiy696	journal	April 2019
Antibody Determinants of Influenza Immunity Crowe, James E. The Journal of Infectious Diseases, Vol. 219, Issue Supplement_1 https://doi.org/10.1093/infdis/jiz010	journal	April 2019
Structure-guided molecular grafting of a complex broadly neutralizing viral epitope Bajic, Goran; Maron, Max J.; Tian, Ming ACS Infectious Diseases https://doi.org/10.1101/860825	journal	December 2019
Minding the gap: The impact of B‐cell tolerance on the microbial antibody repertoire Finney, Joel; Watanabe, Akiko; Kelsoe, Garnett Immunological Reviews, Vol. 292, Issue 1 https://doi.org/10.1111/imr.12805	journal	September 2019
Visualizing antibody affinity maturation in germinal centers Tas, J. M. J.; Mesin, L.; Pasqual, G. Science, Vol. 351, Issue 6277 https://doi.org/10.1126/science.aad3439	journal	February 2016
Preferential induction of cross-group influenza A hemagglutinin stem–specific memory B cells after H7N9 immunization in humans Andrews, Sarah F.; Joyce, M. Gordon; Chambers, Michael J. Science Immunology, Vol. 2, Issue 13 https://doi.org/10.1126/sciimmunol.aan2676	journal	July 2017
Self-tolerance curtails the B cell repertoire to microbial epitopes Watanabe, Akiko; Su, Kuei-Ying; Kuraoka, Masayuki JCI Insight, Vol. 4, Issue 10 https://doi.org/10.1172/jci.insight.122551	journal	May 2019
Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains Turner, Hannah L.; Pallesen, Jesper; Lang, Shanshan PLOS Biology, Vol. 17, Issue 2 https://doi.org/10.1371/journal.pbio.3000139	journal	February 2019
Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice Kil, Laurens P.; Vaneman, Joost; van der Lubbe, Joan E. M. PLOS ONE, Vol. 14, Issue 11 https://doi.org/10.1371/journal.pone.0225063	journal	November 2019
The Hard Way towards an Antibody-Based HIV-1 Env Vaccine: Lessons from Other Viruses Ringel, Oliver; Vieillard, Vincent; Debré, Patrice Viruses, Vol. 10, Issue 4 https://doi.org/10.3390/v10040197	journal	April 2018
Clinical Advances in Viral-Vectored Influenza Vaccines Sebastian, Sarah; Lambe, Teresa Vaccines, Vol. 6, Issue 2 https://doi.org/10.3390/vaccines6020029	journal	May 2018
Influenza Virus–Specific Human Antibody Repertoire Studies Crowe, James E. The Journal of Immunology, Vol. 202, Issue 2 https://doi.org/10.4049/jimmunol.1801459	journal	January 2019
Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site Following Vaccination of Humans Zost, Seth J.; Lee, Juhye; Gumina, Megan E. SSRN Electronic Journal https://doi.org/10.2139/ssrn.3417940	journal	January 2019
Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses Joyce, M. Gordon; Wheatley, Adam K.; Thomas, Paul V. Cell, Vol. 166, Issue 3 https://doi.org/10.1016/j.cell.2016.06.043	journal	July 2016
Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site Schmidt, Aaron G.; Do, Khoi T.; McCarthy, Kevin R. Cell Reports, Vol. 13, Issue 12 https://doi.org/10.1016/j.celrep.2015.11.063	journal	December 2015
Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site following Vaccination of Humans Zost, Seth J.; Lee, Juhye; Gumina, Megan E. Cell Reports, Vol. 29, Issue 13 https://doi.org/10.1016/j.celrep.2019.11.084	journal	December 2019
Structural Insights for Anti-Influenza Vaccine Design Han, Lifen; Chen, Cong; Han, Xianlin Computational and Structural Biotechnology Journal, Vol. 17 https://doi.org/10.1016/j.csbj.2019.03.009	journal	January 2019
Origins of a Vaccine-Induced, Human Anti-HIV-1 Antibody Julien, Jean-Philippe EBioMedicine, Vol. 2, Issue 7 https://doi.org/10.1016/j.ebiom.2015.07.019	journal	July 2015
Influenza Hemagglutinin Structures and Antibody Recognition Wu, Nicholas C.; Wilson, Ian A. Cold Spring Harbor Perspectives in Medicine, Vol. 10, Issue 8 https://doi.org/10.1101/cshperspect.a038778	journal	December 2019
Combination of the immunization with the sequence close to the consensus sequence and two DNA prime plus one VLP boost generate H5 hemagglutinin specific broad neutralizing antibodies Wang, Guiqin; Yin, Renfu; Zhou, Paul PLOS ONE, Vol. 12, Issue 5 https://doi.org/10.1371/journal.pone.0176854	journal	May 2017
Characterization of Hemagglutinin Antigens on Influenza Virus and within Vaccines Using Electron Microscopy Gallagher, John; McCraw, Dustin; Torian, Udana Vaccines, Vol. 6, Issue 2 https://doi.org/10.3390/vaccines6020031	journal	May 2018
ICAMs support B cell interactions with T follicular helper cells and promote clonal selection. Zaretsky, Irina; Atrakchi, Ofir; Mazor, Roei D. Rockefeller Univ. Press https://doi.org/10.7892/boris.111256	text	January 2017

Similar Records

Potent Henipavirus Neutralization by Antibodies Recognizing Diverse Sites on Hendra and Nipah Virus Receptor Binding Protein

Journal Article · Mon Dec 21 00:00:00 EST 2020 · Cell · OSTI ID:1183602

Dong, Jinhui; Cross, Robert W.; Doyle, Michael P.; +13 more

Potent Henipavirus Neutralization by Antibodies Recognizing Diverse Sites on Hendra and Nipah Virus Receptor Binding Protein

Journal Article · Tue Dec 01 00:00:00 EST 2020 · Cell · OSTI ID:1183602

Dong, Jinhui; Cross, Robert W.; Doyle, Michael P.; +13 more

Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus

Journal Article · Wed Oct 15 00:00:00 EDT 2014 · EMBO J. · OSTI ID:1183602

Thomson, Christy A.; Bryson, Steve; McLean, Gary R.; +3 more

Title: Viral Receptor-Binding Site Antibodies with Diverse Germline Origins

Citation Formats

References (40)

Cited By (37)

Similar Records

Related Subjects