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Title: Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain

Journal Article · · Biochemistry-US
DOI:https://doi.org/10.1021/bi501462g· OSTI ID:1183592
; ; ; ;  [1]
  1. Kentucky
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Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
UNIVERSITYNIH
OSTI ID:
1183592
Journal Information:
Biochemistry-US, Vol. 54, Issue (15) ; 04, 2015
Country of Publication:
United States
Language:
ENGLISH
Citation Metrics:
Cited by: 7 works
Citation information provided by
Web of Science

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The sugars in chromomycin A3 stabilize the magnesium(2+)-dimer complex journal January 1993
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Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput Screening journal June 2011
Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells journal July 2012
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Ketopremithramycins and Ketomithramycins, Four New Aureolic Acid-Type Compounds Obtained upon Inactivation of Two Genes Involved in the Biosynthesis of the Deoxysugar Moieties of the Antitumor Drug Mithramycin by Streptomyces A rgillaceus , Reveal Novel Insights into Post-PKS Tailoring Steps of the Mithramycin Biosynthetic Pathway journal February 2002
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties journal February 2001
Elucidation of the Glycosylation Sequence of Mithramycin Biosynthesis: Isolation of 3A-Deolivosylpremithramycin B and Its Conversion to Premithramycin B by Glycosyltransferase MtmGII journal February 2005
Cooperation of Two Bifunctional Enzymes in the Biosynthesis and Attachment of Deoxysugars of the Antitumor Antibiotic Mithramycin journal September 2012
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
The long-wavelength limit of the structure factor of amorphous silicon and vitreous silica journal December 2009
Molecular Architecture of a C- 3′-Methyltransferase Involved in the Biosynthesis of d -Tetronitrose journal July 2010
Basic local alignment search tool journal October 1990
Probing the catalytic mechanism of a C-3′-methyltransferase involved in the biosynthesis of D-tetronitrose journal April 2012
Biosynthesis of the unusual 5,5-gem-dimethyl-deoxysugar noviose: investigation of the C-methyltransferase gene cloU journal August 2006
Identification of the Coumermycin A1 Biosynthetic Gene Cluster of Streptomyces rishiriensis DSM 40489 journal November 2000
Methyltransferase genes in Streptomyces rishiriensis: new coumermycin derivatives from gene-inactivation experiments b bThe GenBank accession number for the sequence reported in this paper is AF235050. journal October 2002
Functional characterizations of novWUS involved in novobiocin biosynthesis from Streptomyces spheroides journal April 2005
Characterization of Tiacumicin B Biosynthetic Gene Cluster Affording Diversified Tiacumicin Analogues and Revealing a Tailoring Dihalogenase journal February 2011
Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea journal April 1998
Biosynthesis of TDP- l -Mycarose:  The Specificity of a Single Enzyme Governs the Outcome of the Pathway journal July 2005
Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tü57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1 The GenBank accession number for the sequence reported in this paper is AF333038. journal February 2002
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The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures journal October 2001
Deoxysugars in glycopeptide antibiotics: Enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis journal October 2000

Cited By (4)

Post-PKS enzyme complexes journal January 2019
Selvamicin, an atypical antifungal polyene from two alternative genomic contexts journal November 2016
A pharmaceutical model for the molecular evolution of microbial natural products journal November 2019
Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives journal November 2016

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