Experimental Limiting Oxygen Concentrations for Nine Organic Solvents at Temperatures and Pressures Relevant to Aerobic Oxidations in the Pharmaceutical Industry
- Fauske & Associates, Burr Ridge, Illinois 60527, United States
- Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States
- Merck Research Laboratories, Rahway, New Jersey 07065, United States
- Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States
- Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States
- Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States
Applications of aerobic oxidation methods in pharmaceutical manufacturing are limited in part because mixtures of oxygen gas and organic solvents often create the potential for a flammable atmosphere. To address this issue, limiting oxygen concentration (LOC) values, which define the minimum partial pressure of oxygen that supports a combustible mixture, have been measured for nine commonly used organic solvents at elevated temperatures and pressures. The solvents include acetic acid, N-methylpyrrolidone, dimethyl sulfoxide, tert-amyl alcohol, ethyl acetate, 2-methyltetrahydrofuran, methanol, acetonitrile, and toluene. Furthermore, the data obtained from these studies help define safe operating conditions for the use of oxygen with organic solvents.
- Research Organization:
- Univ. of Wisconsin, Madison, WI (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- Grant/Contract Number:
- FG02-05ER15690
- OSTI ID:
- 1179621
- Alternate ID(s):
- OSTI ID: 1346922
- Journal Information:
- Organic Process Research & Development, Journal Name: Organic Process Research & Development Vol. 19 Journal Issue: 11; ISSN 1083-6160
- Publisher:
- American Chemical SocietyCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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