skip to main content

This content will become publicly available on December 6, 2015

Title: Experimental limiting oxygen concentrations for nine organic solvents at temperatures and pressures relevant to aerobic oxidations in the pharmaceutical industry

Applications of aerobic oxidation methods in pharmaceutical manufacturing are limited in part because mixtures of oxygen gas and organic solvents often create the potential for a flammable atmosphere. To address this issue, limiting oxygen concentration (LOC) values, which define the minimum partial pressure of oxygen that supports a combustible mixture, have been measured for nine commonly used organic solvents at elevated temperatures and pressures. The solvents include acetic acid, N-methylpyrrolidone, dimethyl sulfoxide, tert-amyl alcohol, ethyl acetate, 2-methyltetrahydrofuran, methanol, acetonitrile, and toluene. Furthermore, the data obtained from these studies help define safe operating conditions for the use of oxygen with organic solvents.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [2] ;  [1] ;  [5] ;  [5]
  1. Fauske & Assoc., Burr Ridge, IL (United States)
  2. Eli Lilly and Co., Indianapolis, IN (United States)
  3. Merck Research Lab., Rahway, NJ (United States)
  4. Pfizer Worldwide Research and Development, Groton, CT (United States)
  5. Univ. of Wisconsin, Madison, WI (United States)
Publication Date:
OSTI Identifier:
1179621
Grant/Contract Number:
FG02-05ER15690
Type:
Published Article
Journal Name:
Organic Process Research & Development
Additional Journal Information:
Journal Volume: 19; Journal Issue: 11; Journal ID: ISSN 1083-6160
Research Org:
Univ. of Wisconsin, Madison, WI (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES