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Title: Radical S -Adenosylmethionine Enzymes

Journal Article · · Chemical Reviews
DOI:https://doi.org/10.1021/cr4004709· OSTI ID:1179590
 [1];  [1];  [1];  [1]
  1. Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59717, United States
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Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
FG02-10ER16194; SC0005404
OSTI ID:
1179590
Journal Information:
Chemical Reviews, Journal Name: Chemical Reviews Vol. 114 Journal Issue: 8; ISSN 0009-2665
Publisher:
American Chemical SocietyCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 513 works
Citation information provided by
Web of Science

References (628)

Biotin synthase mechanism: on the origin of sulphur journal November 1998
Lysine 2,3-Aminomutase:  Rapid Mix−Freeze−Quench Electron Paramagnetic Resonance Studies Establishing the Kinetic Competence of a Substrate-Based Radical Intermediate † journal January 1996
Rhizobium (Sinorhizobium)meliloti phn Genes: Characterization and Identification of Their Protein Products journal January 1999
Characterization of an Active Spore Photoproduct Lyase, a DNA Repair Enzyme in the Radical S-Adenosylmethionine Superfamily journal September 2006
In Vitro Phosphinate Methylation by PhpK from Kitasatospora phosalacinea journal October 2011
Evidence from Mössbauer Spectroscopy for Distinct [2Fe-2S] 2+ and [4Fe-4S] 2+ Cluster Binding Sites in Biotin Synthase from Escherichia c oli journal August 2002
Spectroscopic Characterization of Site-Specific [Fe 4 S 4 ] Cluster Chemistry in Ferredoxin:Thioredoxin Reductase:  Implications for the Catalytic Mechanism journal July 2005
Biomimetic assembly and activation of [FeFe]-hydrogenases journal June 2013
Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus journal December 2001
Formation of the spore photoproduct and other dimeric lesions between adjacent pyrimidines in UVC-irradiated dry DNA journal January 2003
The oxygen-independent coproporphyrinogen III oxidase HemN utilizes harderoporphyrinogen as a reaction intermediate during conversion of coproporphyrinogen III to protoporphyrinogen IX journal January 2010
Characterization of a molybdenum cofactor biosynthetic gene cluster in Rhodobacter capsulatus which is specific for the biogenesis of dimethylsulfoxide reductase journal June 1999
Reactivity of [Fe 4 S 4 (SR) 4 ] 2-,3- Clusters with Sulfonium Cations:  Analogue Reaction Systems for the Initial Step in Biotin Synthase Catalysis journal June 2001
Lipoyl Synthase Inserts Sulfur Atoms into an Octanoyl Substrate in a Stepwise Manner journal August 2006
Bacteriochlorophyllide c C-82 and C-121 Methyltransferases Are Essential for Adaptation to Low Light in Chlorobaculum tepidum journal June 2007
Thiamin biosynthesis in prokaryotes journal April 1999
Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes journal October 2012
A Radical Transfer Pathway in Spore Photoproduct Lyase journal April 2013
Binding of DNA in vitro by a small, acid-soluble spore protein from Bacillus subtilis and the effect of this binding on DNA topology. journal January 1990
A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases journal March 2011
A connection between iron–sulfur cluster metabolism and the biosynthesis of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate in Salmonella enterica journal August 2006
Crystal Structure of RumA, an Iron-Sulfur Cluster Containing E. coli Ribosomal RNA 5-Methyluridine Methyltransferase journal March 2004
Isolation and properties of the trypsin-derived ADP-ribosyl peptide from diphtheria toxin-modified yeast elongation factor 2. journal December 1978
Experimental Evidence for the Existence of a Stable Half-Barrel Subdomain in the (β/α)8-Barrel Fold journal October 2008
Biosynthetic labeling of diphthamide in Saccharomyces cerevisiae. journal April 1983
Activation of HydA ΔEFG Requires a Preformed [4Fe-4S] Cluster journal July 2009
Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods journal March 2001
Chemical Synthesis, Crystal Structure and Enzymatic Evaluation of a Dinucleotide Spore Photoproduct Analogue Containing a Formacetal Linker journal July 2011
Binding of Exogenously Added Carbon Monoxide at the Active Site of the Iron-Only Hydrogenase (CpI) from Clostridium pasteurianum † , ‡ journal October 1999
Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099 journal January 2010
Characterization of NocL Involved in Thiopeptide Nocathiacin I Biosynthesis journal June 2011
Enzymatic Conversion of Dethiobiotin to Biotin in Cell-free Extracts of a Bacillus sphaericus bioB Transformant journal January 1994
Structure-Function Relationships in [FeFe]-Hydrogenase Active Site Maturation journal March 2012
Naturally occurring 5-deazaflavin coenzymes: biological redox roles journal June 1986
Identification of Four Genes Necessary for Biosynthesis of the Modified Nucleoside Queuosine journal December 2003
Novel Avilamycin Derivatives with Improved Polarity Generated by Targeted Gene Disruption journal October 2004
Iron-Sulfur Center of Biotin Synthase and Lipoate Synthase journal April 2000
Purification and properties of coproporphyrinogen III oxidase from yeast book January 1997
Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme journal July 2012
Direct FeS Cluster Involvement in Generation of a Radical in Lysine 2,3-Aminomutase † journal December 2000
The spectrum of antimicrobial activity of the bacteriocin subtilosin A journal November 2006
Structural characterization reveals that viperin is a radical S-adenosyl-l-methionine (SAM) enzyme journal January 2010
Mechanistic Studies on the Repair of a Novel DNA Photolesion:  The Spore Photoproduct journal October 1999
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) journal May 2002
Molecular characterization of the 1,3-propanediol (1,3-PD) operon of Clostridium butyricum journal April 2003
AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation journal July 2004
Spectroelectrochemical Characterization of the Active Site of the [FeFe] Hydrogenase HydA1 from Chlamydomonas reinhardtii journal August 2009
The lipoate synthase from Escherichia coli is an iron-sulfur protein journal June 1999
Demonstration that fbiC Is Required by Mycobacterium bovis BCG for Coenzyme F420 and FO Biosynthesis journal May 2002
Catalysis of a New Ribose Carbon-Insertion Reaction by the Molybdenum Cofactor Biosynthetic Enzyme MoaA journal February 2013
Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid: Linezolid resistance through ribosome modification journal April 2007
The delta nifB (or delta nifE) FeMo cofactor-deficient MoFe protein is different from the delta nifH protein journal June 1991
Dithiomethylether as a Ligand in the Hydrogenase H-Cluster journal April 2008
C–C bond formation and cleavage in radical enzymes, a theoretical perspective journal February 2005
Escherichia coli Lipoyl Synthase Binds Two Distinct [4Fe−4S] Clusters per Polypeptide † journal September 2004
Hydrogen Transfer in SAM-Mediated Enzymatic Radical Reactions journal November 2012
Unusual sugar biosynthesis and natural product glycodiversification journal April 2007
Comparative Biogenetic Anatomy of Vitamin B 1 : A 13 C NMR Investigation of the Biosynthesis of Thiamin in Escherichia coli and in Saccharomyces cerevisiae journal April 1998
Protein structure prediction on the Web: a case study using the Phyre server journal February 2009
Nucleotide sequence and structure of the Klebsiella pneumoniae pqq operon journal March 1992
Structure of Subtilosin A, an Antimicrobial Peptide from Bacillus s ubtilis with Unusual Posttranslational Modifications Linking Cysteine Sulfurs to α-Carbons of Phenylalanine and Threonine journal April 2003
A Glycyl Radical Site in the Crystal Structure of a Class III Ribonucleotide Reductase journal March 1999
The Activating Component of the Anaerobic Ribonucleotide Reductase from Escherichia coli journal May 2000
The Tetrahydropyranopterin Structure of the Sulfur-free and Metal-free Molybdenum Cofactor Precursor journal February 2004
Insight into the Mechanism of the B 12 -Independent Glycerol Dehydratase from Clostridium butyricum :  Preliminary Biochemical and Structural Characterization ‡ journal April 2004
Discovery and Characterization of BlsE, a Radical S-Adenosyl-L-methionine Decarboxylase Involved in the Blasticidin S Biosynthetic Pathway journal July 2013
A glycyl free radical as the precursor in the synthesis of carbon monoxide and cyanide by the [FeFe]-hydrogenase maturase HydG journal September 2010
The PLP-dependent biotin synthase from Escherichia coli : mechanistic studies journal December 2002
GenK-Catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-Dependent Radical SAM Enzyme journal May 2013
Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria journal December 2009
Elongator Protein 3 (Elp3) Lysine Acetyltransferase Is a Tail-anchored Mitochondrial Protein in Toxoplasma gondii journal August 2013
Spore Photoproduct Lyase Catalyzes Specific Repair of the 5 R but Not the 5 S Spore Photoproduct journal February 2009
NirJ, a radical SAM family member of the d 1 heme biogenesis cluster journal April 2010
tRNA's modifications bring order to gene expression journal April 2008
Biosynthesis of 7-Deazaguanosine-Modified tRNA Nucleosides: a New Role for GTP Cyclohydrolase I journal October 2008
Binding of small acid-soluble spore proteins from Bacillus subtilis changes the conformation of DNA from B to A. journal January 1991
Vesicular stomatitis virus and pseudorabies virus induce a vig1/cig5 homologue in mouse dendritic cells via different pathways The GenBank accession number of the sequence reported in this paper is AF236064. journal November 2000
Sequence analysis of pqq genes required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1 and the purification of a biosynthetic intermediate journal February 1997
Thiazole Synthase from Escherichia coli: AN INVESTIGATION OF THE SUBSTRATES AND PURIFIED PROTEINS REQUIRED FOR ACTIVITY IN VITRO journal April 2007
Biochemical characterization of the HydE and HydG iron-only hydrogenase maturation enzymes from Thermatoga maritima journal August 2005
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton journal August 2011
Spectroscopic Approaches to Elucidating Novel Iron−Sulfur Chemistry in the “Radical-SAM” Protein Superfamily journal February 2005
Possible anticodon sequences of tRNAHis, tRNAAsn, and tRNAAsp from Escherichia coli. Universal presence of nucleoside O in the first position of the anticodons of these transfer ribonucleic acid journal January 1972
Adenosylcobalamin enzymes: Theory and experiment begin to converge journal November 2012
Mechanistic understanding of Pyrococcus horikoshiiDph2, a [4Fe–4S] enzyme required for diphthamidebiosynthesis journal January 2011
Infrared Studies of the CO-Inhibited Form of the Fe-Only Hydrogenase from Clostridium pasteurianum I:  Examination of Its Light Sensitivity at Cryogenic Temperatures † journal February 2002
Coenzyme a Function in and Acetyl Transfer by the Phosphotransacetylase System journal July 1951
Radical S-Adenosylmethionine Enzyme Coproporphyrinogen III Oxidase HemN journal August 2005
Identification of the Proteins Required for Biosynthesis of Diphthamide, the Target of Bacterial ADP-Ribosylating Toxins on Translation Elongation Factor 2 journal November 2004
β-Methylthio-aspartic acid: Identification of a novel posttranslational modification in ribosomal protein S12 from escherichia coli journal August 1996
The role of S-adenosylmethionine in the lysine 2,3-aminomutase reaction. journal November 1987
Chlorophyll Biosynthesis in Bacteria: The Origins of Structural and Functional Diversity journal October 2007
One Fold with Many Functions: The Evolutionary Relationships between TIM Barrel Families Based on their Sequences, Structures and Functions journal August 2002
The history of the discovery of the molybdenum cofactor and novel aspects of its biosynthesis in bacteria journal May 2011
The Thiamine Biosynthetic Enzyme ThiC Catalyzes Multiple Turnovers and Is Inhibited by S -Adenosylmethionine (AdoMet) Metabolites journal September 2013
Two [4Fe-4S] Clusters Containing Radical SAM Enzyme SkfB Catalyze Thioether Bond Formation during the Maturation of the Sporulation Killing Factor journal January 2013
Directed Mutational Analysis of Bacteriochlorophyll a Biosynthesis in Rhodobacter capsulatus journal April 1994
Reduction of Ribonucleotides journal June 1979
Structural bioinformatics analysis of enzymes involved in the biosynthesis pathway of the hypermodified nucleoside ms2io6A37 in tRNA journal October 2007
Lipoyl Synthase Requires Two Equivalents of S -Adenosyl- l -methionine To Synthesize One Equivalent of Lipoic Acid † journal June 2004
Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii journal August 1996
RlmN and Cfr are Radical SAM Enzymes Involved in Methylation of Ribosomal RNA journal March 2010
The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA journal November 2007
Quantum Refinement of [FeFe] Hydrogenase Indicates a Dithiomethylamine Ligand journal April 2010
Thiamine Biosynthesis inEscherichia coli: Identification of the Intermediate and By-Product Derived from Tyrosine journal December 2007
Spectroscopic Evidence for Site Specific Chemistry at a Unique Iron Site of the [4Fe−4S] Cluster in Ferredoxin:Thioredoxin Reductase journal February 2003
Escherichia coliBiotin Synthase: An Investigation into the Factors Required for Its Activity and Its Sulfur Donor journal February 1996
Discovery of a Gene Family Critical to Wyosine Base Formation in a Subset of Phenylalanine-specific Transfer RNAs journal November 2005
Purification and characterization of Desulfovibrio vulgaris (Hildenborough) hydrogenase expressed in Escherichia coli journal January 1987
The Anaerobic Escherichia coli Ribonucleotide Reductase journal April 1996
Deciphering Deazapurine Biosynthesis: Pathway for Pyrrolopyrimidine Nucleosides Toyocamycin and Sangivamycin journal August 2008
Formation and Insertion of the Nitrogenase Iron−Molybdenum Cofactor journal February 2004
Differential regulation of the Fe-hydrogenase during anaerobic adaptation in the green alga Chlamydomonas reinhardtii : Fe-hydrogenase from journal February 2002
Biochemical and Kinetic Characterization of Radical S -Adenosyl- l -methionine Enzyme HydG journal November 2013
The Interferon-Inducible Protein Viperin Inhibits Influenza Virus Release by Perturbing Lipid Rafts journal August 2007
X-ray Structure of the [FeFe]-Hydrogenase Maturase HydE from Thermotoga maritima journal April 2008
Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu journal April 2009
Mechanistic Studies of the Spore Photoproduct Lyase via a Single Cysteine Mutation journal August 2012
The Active Conformation of Avilamycin A Is Conferred by AviX12, a Radical AdoMet Enzyme journal March 2006
Spectroscopic Evidence for the Participation of an Allylic Analogue of the 5‘-Deoxyadenosyl Radical in the Reaction of Lysine 2,3-Aminomutase journal October 1999
Extended X-ray Absorption Fine Structure and Nuclear Resonance Vibrational Spectroscopy Reveal that NifB-co, a FeMo-co Precursor, Comprises a 6Fe Core with an Interstitial Light Atom journal April 2008
Diphthamide biosynthesis requires an organic radical generated by an iron–sulphur enzyme journal June 2010
Functionality of Alternative Splice Forms of the First Enzymes Involved in Human Molybdenum Cofactor Biosynthesis journal May 2002
Assembly of Nitrogenase MoFe Protein † journal April 2008
Radical SAM-Dependent Carbon Insertion into the Nitrogenase M-Cluster journal September 2012
Synthesis of the Dinucleotide Spore Photoproduct journal October 1995
Conversion of 3Fe-4S to 4Fe-4S Clusters in Native Pyruvate Formate-Lyase Activating Enzyme:  Mössbauer Characterization and Implications for Mechanism journal December 2000
The [FeFe]-hydrogenase maturation protein HydF contains a H-cluster like [4Fe4S]-2Fe site journal December 2010
Mechanisms of coenzyme B12-dependent rearrangements journal February 1985
Covalent Intermediate in the Catalytic Mechanism of the Radical S -Adenosyl- l -methionine Methyl Synthase RlmN Trapped by Mutagenesis journal October 2012
Maturation of a hypermodified nucleoside in transfer RNA journal January 1975
Reaction of AdoMet with ThiC Generates a Backbone Free Radical † journal January 2009
Radical Enzymes in Anaerobes journal October 2006
Regulation of Substrate Recognition by the MiaA tRNA Prenyltransferase Modification Enzyme of Escherichia coliK-12 journal May 1997
Desulfovibrio desulfuricans iron hydrogenase: the structure shows unusual coordination to an active site Fe binuclear center journal January 1999
The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences journal February 2000
Genetic analysis of a mutant ofBacillus subtilis producing ultraviolet-sensitive spores journal July 1969
Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC journal November 2007
Self-sacrifice in radical S-adenosylmethionine proteins journal October 2007
Mechanistic Studies of Desosamine Biosynthesis:  C-4 Deoxygenation Precedes C-3 Transamination journal November 1998
Investigation of the Early Steps of Molybdopterin Biosynthesis in Escherichia coli through the Use of in Vivo Labeling Studies journal January 1995
4-Hydroxyphenylacetate Decarboxylases:  Properties of a Novel Subclass of Glycyl Radical Enzyme Systems † journal August 2006
Stabilisation of Methylene Radicals by Cob(II)alamin in Coenzyme B12 Dependent Mutases journal January 2006
D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine journal April 2011
Biosynthesis of the pyrimidine moiety of thiamine. A new route of pyrimidine biosynthesis involving purine intermediates journal January 1968
Subtilosin A, a New Antibiotic Peptide Produced by Bacillus subtilis 168: Isolation, Structural Analysis, and Biogenesis1 journal September 1985
Rearrangement reactions in the biosynthesis of molybdopterin. An NMR study with multiply 13C/15N labelled precursors journal July 1998
Electron Paramagnetic Resonance Evidence for a Novel Interconversion of [3Fe-4S]+ and [4Fe-4S]+Clusters with Endogenous Iron and Sulfide in Anaerobic Ribonucleotide Reductase Activase in Vitro journal April 2000
Functional characterization of the YmcB and YqeV tRNA methylthiotransferases of Bacillus subtilis journal May 2010
Cannibalism by Sporulating Bacteria journal July 2003
The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA journal March 2009
An iron-sulfur center and a free radical in the active anaerobic ribonucleotide reductase of Escherichia coli. journal February 1993
Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus journal January 2007
MiaB Protein from Thermotoga maritima journal August 2003
In vitro synthesis of the iron molybdenum cofactor of nitrogenase from iron, sulfur, molybdenum, and homocitrate using purified proteins journal October 2007
Identification of an Intermediate Methyl Carrier in the Radical S -Adenosylmethionine Methylthiotransferases RimO and MiaB journal October 2013
Incorporation of Iron and Sulfur from NifB Cofactor into the Iron-Molybdenum Cofactor of Dinitrogenase journal November 1995
The crystal structure of C176A mutated [Fe]‐hydrogenase suggests an acyl‐iron ligation in the active site iron complex journal January 2009
Crystal Structure of the Radical SAM Enzyme Catalyzing Tricyclic Modified Base Formation in tRNA journal October 2007
Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine journal August 2013
The structure and mechanism of iron-hydrogenases journal November 1990
Pyruvate Formate-Lyase Reaction in Escherichia coli. The Enzymatic System Converting and Inactive Form of the Lyase into the Catalytically Active Enzyme journal December 1969
Pulsed electron paramagnetic resonance studies of the lysine 2,3-aminomutase substrate radical: Evidence for participation of pyridoxal 5'-phosphate in a radical rearrangement journal August 1995
Interactions of Diol Dehydrase and 3‘,4‘-Anhydroadenosylcobalamin:  Suicide Inactivation by Electron Transfer † journal February 2002
Identification of a Cyclic Nucleotide as a Cryptic Intermediate in Molybdenum Cofactor Biosynthesis journal April 2013
Escherichia coli LipA Is a Lipoyl Synthase:  In Vitro Biosynthesis of Lipoylated Pyruvate Dehydrogenase Complex from Octanoyl-Acyl Carrier Protein † journal December 2000
Small, Acid-Soluble Spore Proteins of Bacillus Species: Structure, Synthesis, Genetics, Function, and Degradation journal October 1988
Fundamentals of H 2 Binding and Reactivity on Transition Metals Underlying Hydrogenase Function and H 2 Production and Storage journal October 2007
High-level expression and reconstitution of active Cfr, a radical-SAM rRNA methyltransferase that confers resistance to ribosome-acting antibiotics journal December 2010
The role of the maturase HydG in [FeFe]‐hydrogenase active site synthesis and assembly journal January 2009
Crystallographic and FTIR Spectroscopic Evidence of Changes in Fe Coordination Upon Reduction of the Active Site of the Fe-Only Hydrogenase from Desulfovibrio d esulfuricans journal February 2001
A Model of the [FeFe] Hydrogenase Active Site with a Biologically Relevant Azadithiolate Bridge: A Spectroscopic and Theoretical Investigation journal January 2011
Best5: a novel interferon‐inducible gene expressed during bone formation journal March 2000
A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity? journal March 2002
DNA Repair and Free Radicals, New Insights into the Mechanism of Spore Photoproduct Lyase Revealed by Single Amino Acid Substitution journal December 2008
Recent advances in chlorophyll biosynthesis journal September 2006
Reconstitution of Dimethylamine:Coenzyme M Methyl Transfer with a Discrete Corrinoid Protein and Two Methyltransferases Purified from Methanosarcina barkeri journal June 2000
The Crystal Structure of an [Fe]-Hydrogenase-Substrate Complex Reveals the Framework for H 2 Activation journal August 2009
Reductive Cleavage of S-Adenosylmethionine by Biotin Synthase from Escherichia coli journal April 2002
Evidence for a new ribonucleotide reductase in anaerobic E.coli journal September 1988
Common fold in helix-hairpin-helix proteins journal July 2000
Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri. journal February 1997
Characterization of a New Thermophilic Spore Photoproduct Lyase from Geobacillus stearothermophilus (SplG) with Defined Lesion Containing DNA Substrates journal November 2006
vig-1, a New Fish Gene Induced by the Rhabdovirus Glycoprotein, Has a Virus-Induced Homologue in Humans and Shares Conserved Motifs with the MoaA Family journal March 1999
Structure of ( E )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway journal December 2008
Radical Carbon Skeleton Rearrangements:  Catalysis by Coenzyme B 12 -Dependent Mutases journal June 2003
Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes journal December 2003
Conversion of Dethiobiotin to Biotin in Cell-free Extracts of Escherichia coli journal January 1992
The 3D Solution Structure of Thurincin H, a Bacteriocin with Four Sulfur to α-Carbon Crosslinks journal July 2011
Biochemical and genetic characterization of benzylsuccinate synthase from Thauera aromatica : a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism journal April 1998
Thiopeptide Antibiotics journal February 2005
The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion journal January 2006
Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria journal February 2009
On the mechanism of conversion of dethiobiotin to biotin in Escherichia coli. journal February 1977
Tracing the Interstitial Carbide of the Nitrogenase Cofactor during Substrate Turnover journal March 2013
Identification of a methylase required for 2-methylhopanoid production and implications for the interpretation of sedimentary hopanes journal April 2010
MiaB, a Bifunctional Radical- S- Adenosylmethionine Enzyme Involved in the Thiolation and Methylation of tRNA, Contains Two Essential [4Fe-4S] Clusters † journal May 2007
Electron-Nuclear Double Resonance Spectroscopic Evidence That S -Adenosylmethionine Binds in Contact with the Catalytically Active [4Fe−4S] + Cluster of Pyruvate Formate-Lyase Activating Enzyme journal March 2002
QM/MM study of the conversion mechanism of lysine to methylornithine catalyzed by methylornithine synthase (PylB) journal July 2013
Protein Residues That Control the Reaction Trajectory in S- Adenosylmethionine Radical Enzymes: Mutagenesis of Asparagine 153 and Aspartate 155 in Escherichia coli Biotin Synthase † journal March 2009
Cobalt-carbon bond dissociation energy of coenzyme B12 journal December 1984
The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A journal February 2012
Reactions of site-differentiated [Fe4S4]2+,1+ clusters with sulfonium cations: reactivity analogues of biotin synthase and other members of the S-adenosylmethionine enzyme family journal November 2003
Thymine-containing dimers as well as spore photoproducts are found in ultraviolet-irradiated Bacillus subtilis spores that lack small acid-soluble proteins. journal January 1987
Pyruvate formate-lyase (inactive form) and pyruvate formate-lyase activating enzyme of Escherichia coli: Isolation and structural properties journal January 1984
The in vitro synthesis of 2′-omethylguanosine and 2-methylthio 6 N (γ,γ, dimethylallyl) adenosine in transfer RNA of Escherichia coli journal August 1969
Lipoic acid metabolism in Escherichia coli: sequencing and functional characterization of the lipA and lipB genes. journal January 1993
X-ray Emission Spectroscopy Evidences a Central Carbon in the Nitrogenase Iron-Molybdenum Cofactor journal November 2011
Coordination and Mechanism of Reversible Cleavage of S -Adenosylmethionine by the [4Fe-4S] Center in Lysine 2,3-Aminomutase journal October 2003
Menaquinone Biosynthesis: Formation of Aminofutalosine Requires a Unique Radical SAM Enzyme journal October 2013
Structural Basis for Methyl Transfer by a Radical SAM Enzyme journal April 2011
Functional Studies of [FeFe] Hydrogenase Maturation in an Escherichia coli Biosynthetic System journal March 2006
Lysine 2,3-Aminomutase journal April 1970
Pyrroloquinoline Quinone Biogenesis: Demonstration That PqqE from Klebsiella pneumoniae Is a Radical S -Adenosyl- l -methionine Enzyme journal October 2009
Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis journal August 2010
Characterization of RimO, a New Member of the Methylthiotransferase Subclass of the Radical SAM Superfamily journal October 2009
The Structure of the Active Site H-Cluster of [FeFe] Hydrogenase from the Green Alga Chlamydomonas reinhardtii Studied by X-ray Absorption Spectroscopy journal June 2009
The antiviral protein viperin is a radical SAM enzyme journal February 2010
Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase: A small subunit, HpdC, is essential for catalytic activity journal May 2004
Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs journal December 1997
Radical AdoMet enzymes in complex metal cluster biosynthesis journal November 2012
The Iron−Sulfur Cluster of Pyruvate Formate-Lyase Activating Enzyme in Whole Cells: Cluster Interconversion and a Valence-Localized [4Fe-4S] 2+ State journal October 2009
How an Enzyme Tames Reactive Intermediates:  Positioning of the Active-Site Components of Lysine 2,3-Aminomutase during Enzymatic Turnover As Determined by ENDOR Spectroscopy journal August 2006
The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics journal July 2006
A Drosophila approach to thyroid cancer therapeutics journal March 2013
An Alternative Menaquinone Biosynthetic Pathway Operating in Microorganisms journal September 2008
Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS journal November 2011
Essential Cysteine Residues in Bacillus subtilis Spore Photoproduct Lyase Identified by Alanine Scanning Mutagenesis journal September 2005
Mechanistic Studies of the Radical S -Adenosyl- l -methionine Enzyme DesII: EPR Characterization of a Radical Intermediate Generated During Its Catalyzed Dehydrogenation of TDP- d -Quinovose journal May 2011
Characterization and Mechanistic Studies of DesII: A Radical S- Adenosyl- l -methionine Enzyme Involved in the Biosynthesis of TDP- d -Desosamine journal October 2009
Activation of lysine 2,3-aminomutase by S-adenosylmethionine. journal October 1990
Reversibility of the Phosphoroclastic Split of Pyruvate journal April 1945
The [Fe-Fe]-Hydrogenase Maturation Protein HydF from Thermotoga maritima Is a GTPase with an Iron-Sulfur Cluster journal November 2005
Radicals in enzymatic catalysis—a thermodynamic perspective journal January 2010
The Iron Sulfur Protein AtsB Is Required for Posttranslational Formation of Formylglycine in the Klebsiella Sulfatase journal May 1999
Assembly of 2Fe-2S and 4Fe-4S Clusters in the Anaerobic Ribonucleotide Reductase from Escherichia c oli journal July 1999
Biosynthesis of the Pyrrolopyrimidine Nucleoside Antibiotic, Toyocamycin journal September 1970
Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice journal September 2011
X-ray Spectroscopic Observation of an Interstitial Carbide in NifEN-Bound FeMoco Precursor journal December 2012
Prokaryotic photosynthesis and phototrophy illuminated journal November 2006
Characterization of Yatakemycin Gene Cluster Revealing a Radical S -Adenosylmethionine Dependent Methyltransferase and Highlighting Spirocyclopropane Biosynthesis journal May 2012
The Free Radical of the Anaerobic Ribonucleotide Reductase from Escherichia coli Is at Glycine 681 journal March 1996
Biosynthesis of pyrroloquinoline quinone. 2. Biosynthetic assembly from glutamate and tyrosine journal April 1991
Ribonucleotide Reductases journal June 1998
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism journal April 2006
Studies on A New Biosynthetic Pathway for Menaquinone journal April 2008
Biosynthesis of complex iron–sulfur enzymes journal April 2011
Molecular genetic analysis of the moa operon of Escherichia coli K-12 required for molybdenum cofactor biosynthesis journal June 1993
Inactivation of E. coli pyruvate formate-lyase: Role of AdhE and small molecules journal March 2007
The Residue Mass of L-Pyrrolysine in Three Distinct Methylamine Methyltransferases journal August 2005
[FeFe]-Hydrogenase Maturation: HydG-Catalyzed Synthesis of Carbon Monoxide journal July 2010
Spermicidal bacteriocins: Lacticin 3147 and subtilosin A journal May 2008
Nuclear Resonance Vibrational Spectroscopy and Electron Paramagnetic Resonance Spectroscopy of 57 Fe-Enriched [FeFe] Hydrogenase Indicate Stepwise Assembly of the H-Cluster journal January 2013
High-Pressure Liquid Chromatography Assay for Quantitatively Monitoring Spore Photoproduct Repair Mediated by Spore Photoproduct Lyase during Germination of uv-Irradiated Bacillus subtilis Spores journal August 1994
Mutagenesis of the proposed iron-sulfur cluster binding ligands in Escherichia coli biotin synthase journal January 2000
Human sulfatases: A structural perspective to catalysis journal June 2007
An Anchoring Role for FeS Clusters:  Chelation of the Amino Acid Moiety of S-Adenosylmethionine to the Unique Iron Site of the [4Fe−4S] Cluster of Pyruvate Formate-Lyase Activating Enzyme journal September 2002
Identification of the miaB Gene, Involved in Methylthiolation of Isopentenylated A37 Derivatives in the tRNA of Salmonella typhimurium andEscherichia coli journal December 1999
Post-translational activation introduces a free radical into pyruvate formate-lyase. journal March 1984
The path of lysine to pyrrolysine journal August 2013
Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases journal March 2013
Spectroscopic Characterization of the Isolated Iron-Molybdenum Cofactor (FeMoco) Precursor from the Protein NifEN journal July 2011
A Novel Type of Iron Hydrogenase in the Green Alga Scenedesmus obliquus Is Linked to the Photosynthetic Electron Transport Chain journal November 2000
In Vitro Reconstitution of the Radical S -Adenosylmethionine Enzyme MqnC Involved in the Biosynthesis of Futalosine-Derived Menaquinone journal June 2013
A Consensus Mechanism for Radical SAM-Dependent Dehydrogenation? BtrN Contains Two [4Fe-4S] Clusters journal May 2010
The Structure of a Biosynthetic Intermediate of Pyrroloquinoline Quinone (PQQ) and Elucidation of the Final Step of PQQ Biosynthesis journal May 2004
The subunit structure and catalytic mechanism of the Bacillus subtilis DNA repair enzyme spore photoproduct lyase journal July 2001
Dinucleotide Spore Photoproduct, a Minimal Substrate of the DNA Repair Spore Photoproduct Lyase Enzyme from Bacillus subtilis journal September 2006
Rhodobacter capsulatus genes involved in early steps of the bacteriochlorophyll biosynthetic pathway. journal January 1990
Anaerobic and aerobic coproporphyrinogen III oxidases of Rhodopseudomonas spheroides. Mechanism and stereochemistry of vinyl group formation journal March 1983
Polarography of Sulfonium Salts journal January 1953
Primary structures of Escherichia coli pyruvate formate-lyase and pyruvate-formate-lyase-activating enzyme deduced from the DNA nucleotide sequences journal October 1988
Ultraviolet irradiation of DNA complexed with alpha/beta-type small, acid-soluble proteins from spores of Bacillus or Clostridium species makes spore photoproduct but not thymine dimers. journal October 1991
The Anaerobic Ribonucleotide Reductase from Escherichia coli journal October 1999
Metabolic Flux in Both the Purine Mononucleotide and Histidine Biosynthetic Pathways Can Influence Synthesis of the Hydroxymethyl Pyrimidine Moiety of Thiamine in Salmonella enterica journal November 2002
Further Characterization of Cys-Type and Ser-Type Anaerobic Sulfatase Maturating Enzymes Suggests a Commonality in the Mechanism of Catalysis journal April 2013
The Anaerobic Ribonucleotide Reductase from Lactococcus lactis journal September 2001
Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile journal April 2010
Biosynthesis and transcriptional analysis of thurincin H, a tandem repeated bacteriocin genetic locus, produced by Bacillus thuringiensis SF361 journal October 2009
Expression of two [Fe]-hydrogenases in Chlamydomonas reinhardtii under anaerobic conditions: Expression of a second [Fe]-hydrogenase in C. reinhardtii journal June 2003
Hydrogenases from Methanogenic Archaea, Nickel, a Novel Cofactor, and H 2 Storage journal June 2010
Escherichia coli QueD Is a 6-Carboxy-5,6,7,8-tetrahydropterin Synthase † journal March 2009
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily journal October 2008
Identification of FeS clusters in the glycyl-radical enzyme benzylsuccinate synthase via EPR and Mössbauer spectroscopy journal August 2011
4-Demethylwyosine Synthase from Pyrococcus abyssi Is a Radical-S-adenosyl-l-methionine Enzyme with an Additional [4Fe-4S]+2 Cluster That Interacts with the Pyruvate Co-substrate journal November 2012
Maturation of Nitrogenase: a Biochemical Puzzle journal January 2005
A novel reaction of S-adenosyl-L-methionine correlated with the activation of pyruvate formate-lyase journal August 1976
Adenosylmethionine-dependent synthesis of the glycyl radical in pyruvate formate-lyase by abstraction of the glycine C-2 pro-S hydrogen atom. Studies of [2H]glycine-substituted enzyme and peptides homologous to the glycine 734 site. journal April 1994
Post-translational Modification of Ribosomal Proteins journal February 2010
Pyruvate Formate-Lyase Activating Enzyme Is an Iron−Sulfur Protein journal August 1997
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33 journal January 2012
Structural and Mechanistic Studies on ThiO, a Glycine Oxidase Essential for Thiamin Biosynthesis in Bacillus subtilis † , ‡ journal March 2003
Further Characterization of the [FeFe]-Hydrogenase Maturase HydG journal February 2011
Crystal Structure of Biotin Synthase, an S-Adenosylmethionine-Dependent Radical Enzyme journal January 2004
Pyruvate Is the Source of the Two Carbons That Are Required for Formation of the Imidazoline Ring of 4-Demethylwyosine journal December 2011
3-(3-Amino-3-carboxypropyl)uridine. Novel modified nucleoside isolated from Escherichia coli phenylalanine transfer ribonucleic acid journal June 1974
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase journal August 2000
Primary structure at the site in beef and wheat elongation factor 2 of ADP-ribosylation by diphtheria toxin journal July 1979
Biotin Synthase Is a Pyridoxal Phosphate-Dependent Cysteine Desulfurase journal July 2002
Biotin Synthase, a New Member of the Family of Enzymes Which Uses S-Adenosylmethionine as a Source of Deoxyadenosyl Radical journal July 1997
Synthesis and Stereochemical Assignment of DNA Spore Photoproduct Analogues journal August 2006
Identification of gntK, a gene required for the methylation of purpurosamine C-6′ in gentamicin biosynthesis journal January 2012
Escherichia coli Dimethylallyl Diphosphate:tRNA Dimethylallyltransferase:  A Binding Mechanism for Recombinant Enzyme † journal January 1997
Novel Enzymatic Mechanisms in Carbohydrate Metabolism journal December 2000
Structure of Precursor-Bound NifEN: A Nitrogenase FeMo Cofactor Maturase/Insertase journal January 2011
Transition-state theoretical interpretation of the catalytic power of pyruvate decarboxylases: the roles of static and dynamical considerations journal June 1998
Large-Scale Production of Coenzyme F420-5,6 by Using Mycobacterium smegmatis journal November 2002
Molybdenum cofactors, enzymes and pathways journal August 2009
Aerobic and Anaerobic Mg-Protoporphyrin Monomethyl Ester Cyclases in Purple Bacteria: A STRATEGY ADOPTED TO BYPASS THE REPRESSIVE OXYGEN CONTROL SYSTEM journal November 2003
Identification of Eukaryotic and Prokaryotic Methylthiotransferase for Biosynthesis of 2-Methylthio-N6-threonylcarbamoyladenosine in tRNA journal September 2010
Biosynthesis of diphthamide in Saccharomyces cerevisiae. Partial purification and characterization of a specific S-adenosylmethionine:elongation factor 2 methyltransferase. journal August 1988
RNA methylation by Radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift journal February 2011
Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics journal June 2001
Aconitase as Iron−Sulfur Protein, Enzyme, and Iron-Regulatory Protein journal January 1996
Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism journal December 2013
Intermediates in the transformation of phosphonates to phosphate by bacteria journal November 2011
Viperin: a radical response to viral infection journal June 2012
Pyruvate Formate-Lyase-Activating Enzyme: Strictly Anaerobic Isolation Yields Active Enzyme Containing a [3Fe–4S]+ Cluster journal March 2000
Mössbauer studies of Escherichia coli biotin synthase: evidence for reversible interconversion between [2Fe-2S] 2+ and [4Fe-4S] 2+ clusters journal October 1999
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors journal June 2003
Genes of the sbo-alb Locus ofBacillus subtilis Are Required for Production of the Antilisterial Bacteriocin Subtilosin journal December 1999
Aerobic and Anaerobic Coproporphyrinogenase Activities in Extracts from Saccharomyces cerevisiae journal October 1974
Crystal Structures and Repair Studies Reveal the Identity and the Base-Pairing Properties of the UV-Induced Spore Photoproduct DNA Lesion journal July 2011
The Anaerobic (Class III) Ribonucleotide Reductase fromLactococcus lactis journal January 2000
Reconstitution of Monomethylamine:Coenzyme M Methyl Transfer with a Corrinoid Protein and Two Methyltransferases Purified from Methanosarcina barkeri journal June 1997
Inhibition of Lysine 2,3-Aminomutase by the Alternative Substrate 4-Thialysine and Characterization of the 4-Thialysyl Radical Intermediate journal March 2001
Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold journal May 2010
Biosynthesis of TDP-D-Desosamine: Identification of a Strategy for C4 Deoxygenation journal October 2005
ThiC Is an [Fe-S] Cluster Protein That Requires AdoMet To Generate the 4-Amino-5-hydroxymethyl-2-methylpyrimidine Moiety in Thiamin Synthesis † journal September 2008
Dark repair of DNA containing “spore photoproduct” in Bacillus subtilis journal September 1974
DNA Repair by Spore Photoproduct Lyase:  A Density Functional Theory Study journal October 2003
Anaerobic functionalization of unactivated C–H bonds journal February 2009
Glycyl radical enzymes: a conservative structural basis for radicals journal November 1999
Biosynthesis of the Iron-Molybdenum Cofactor of Nitrogenase journal October 2008
9-Mercaptodethiobiotin Is Formed as a Competent Catalytic Intermediate by Escherichia coli Biotin Synthase † journal September 2008
Probing the Reaction Mechanism of Spore Photoproduct Lyase (SPL) via Diastereoselectively Labeled Dinucleotide SP TpT Substrates journal July 2011
Nucleotide sequence and organization of the multiresistance plasmid pSCFS1 from Staphylococcus sciuri journal November 2004
Direct H Atom Abstraction from Spore Photoproduct C-6 Initiates DNA Repair in the Reaction Catalyzed by Spore Photoproduct Lyase:  Evidence for a Reversibly Generated Adenosyl Radical Intermediate journal March 2002
Highly Purified Biotin Synthase Can Transform Dethiobiotin into Biotin in the Absence of Any Other Protein, in the Presence of Photoreduced Deazaflavin journal December 1995
Spore Photoproduct (SP) Lyase from Bacillus subtilisSpecifically Binds to and Cleaves SP (5-Thyminyl-5,6-Dihydrothymine) but Not Cyclobutane Pyrimidine Dimers in UV-Irradiated DNA journal January 2000
Sixty years of thiamin diphosphate biochemistry journal June 1998
Biosynthesis of the modified peptide antibiotic thiostrepton in Streptomyces azureus and Streptomyces laurentii journal September 1993
Gene cluster for dissimilatory nitrite reductase (nir) from Pseudomonas aeruginosa: sequencing and identification of a locus for heme d1 biosynthesis. journal January 1997
Genome Mining for Radical SAM Protein Determinants Reveals Multiple Sactibiotic-Like Gene Clusters journal July 2011
Coproporphyrinogen oxidase. I. Purification, properties, and activation by phospholipids. journal May 1980
Catalytic Mechanism of the Glycyl Radical Enzyme 4-Hydroxyphenylacetate Decarboxylase from Continuum Electrostatic and QC/MM Calculations journal September 2013
Coproporphyrinogenase activities in extracts of Rhodopseudomonas spheroides and Chromatium strain D journal August 1972
Rings, Radicals, and Regeneration: The Early Years of a Bioorganic Laboratory journal December 2006
Stereochemistry of lysine 2,3-aminomutase isolated from Clostridium subterminale strain SB4 journal August 1983
RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli journal February 2008
Converging on a mechanism for choline degradation journal December 2012
Activation of Class III Ribonucleotide Reductase from E. coli . The Electron Transfer from the Iron−Sulfur Center to S -Adenosylmethionine † journal June 2001
Lysine 2,3‐aminomutase: is adenosylmethionine a poor man's adenosylcobalamin? journal May 1993
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: Architecture of metabolic diversity journal October 1998
Posttranslational Modification of Serine to Formylglycine in Bacterial Sulfatases journal January 2003
Adenosyl coenzyme and pH dependence of the [4Fe–4S]2+/1+ transition in lysine 2,3-aminomutase journal June 2003
A radically different enzyme journal June 2010
Mechanistic Investigations of Anaerobic Sulfatase-Maturating Enzyme: Direct C β H-Atom Abstraction Catalyzed by a Radical AdoMet Enzyme journal June 2009
Insights into [FeFe]-Hydrogenase Structure, Mechanism, and Maturation journal August 2011
Identification and DNA sequence of fixZ , a nifB -like gene from Rhizobium legummosarum journal January 1984
Biosynthesis of vitamin K (menaquinone) in bacteria journal September 1982
Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination journal October 2008
Anaerobic chlorophyll isocyclic ring formation in Rhodobacter capsulatus requires a cobalamin cofactor journal June 2000
Gene inactivation study of gntE reveals its role in the first step of pseudotrisaccharide modifications in gentamicin biosynthesis journal August 2008
The free radical in pyruvate formate-lyase is located on glycine-734. journal February 1992
Identification of Three Interferon-Inducible Cellular Enzymes That Inhibit the Replication of Hepatitis C Virus journal December 2007
PqqC/D, which converts a biosynthetic intermediate to pyrroloquinoline quinone journal November 2002
Biotin biosynthesis. 1. The incorporation of specifically tritiated dethiobiotin into biotin journal June 1976
Structure of a protein-DNA complex essential for DNA protection in spores of Bacillus species journal February 2008
Investigations on the biogenesis of chlorophyll a journal April 1968
A third type of hydrogenase catalyzing H2 activation journal January 2007
Biotin Synthase Contains Two Distinct Iron−Sulfur Cluster Binding Sites:  Chemical and Spectroelectrochemical Analysis of Iron−Sulfur Cluster Interconversions † journal July 2001
Structural genes for thiamine biosynthetic enzymes (thiCEFGH) in Escherichia coli K-12. journal February 1993
Biosynthesis of the modified nucleoside Q in transfer RNA journal February 1976
Synthetic and biosynthetic studies of porphyrins, part V: Evidence for an alternative pathway in the biosynthesis of haem journal January 1980
FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells journal January 2010
Lysine 2,3-Aminomutase and trans -4,5-Dehydrolysine:  Characterization of an Allylic Analogue of a Substrate-Based Radical in the Catalytic Mechanism † journal August 2000
In vitro activation of [FeFe] hydrogenase: new insights into hydrogenase maturation journal March 2007
Identification of the 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase required for coenzyme F 420 biosynthesis journal December 2003
Catalytic Activity of the Anaerobic Tyrosine Lyase Required for Thiamine Biosynthesis in Escherichia coli journal November 2009
Structure of a substrate radical intermediate in the reaction of lysine 2,3-aminomutase journal November 1992
Anaerobic Sulfatase-Maturating Enzymes:  Radical SAM Enzymes Able To Catalyze in Vitro Sulfatase Post-translational Modification journal March 2007
The pterin molybdenum cofactors. journal May 1992
An organic radical in the lysine 2,3-aminomutase reaction journal February 1992
ADP-ribosylation of elongation factor 2 by diphtheria toxin. Isolation and properties of the novel ribosyl-amino acid and its hydrolysis products. journal November 1980
Molecular hijacking of siroheme for the synthesis of heme and d1 heme journal October 2011
Discovery of Two Novel Radical S -Adenosylmethionine Proteins Required for the Assembly of an Active [Fe] Hydrogenase journal April 2004
Radical SAM Activation of the B 12 -Independent Glycerol Dehydratase Results in Formation of 5′-Deoxy-5′-(methylthio)adenosine and Not 5′-Deoxyadenosine journal February 2011
Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine journal September 1975
Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans journal August 2004
Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution journal February 2000
The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale journal September 2005
A radical solution for the biosynthesis of the H-cluster of hydrogenase journal December 2005
Elongation Factor 2 journal August 1974
Nucleoside antibiotics. VI. Biosynthesis of the pyrrolopyrimidine nucleoside antibiotic toyocamycin by Streptomyces rimosus journal March 1970
A late methanogen origin for molybdenum-dependent nitrogenase: A late methanogen origin for Mo-nitrogenase journal April 2011
Generation of adenosyl radical from S-adenosylmethionine (SAM) in biotin synthase journal June 2011
Mechanistic Study on the Reaction of a Radical SAM Dehydrogenase BtrN by Electron Paramagnetic Resonance Spectroscopy † journal August 2008
The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair journal January 2013
Characterization of iron-sulfur clusters in lysine 2,3-aminomutase by electron paramagnetic resonance spectroscopy journal November 1992
The biochemistry of heme biosynthesis journal June 2008
Anaerobic Sulfatase-maturating Enzymes, First Dual Substrate Radical S-Adenosylmethionine Enzymes* journal June 2008
Lysine 2,3-aminomutase: role of S-adenosyl-L-methionine in the mechanism. Demonstration of tritium transfer from (2RS,3RS)-[3-3H]lysine to S-adenosyl-L-methionine journal January 1991
Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily journal January 2010
Structural Characterization of the Enzyme−Substrate, Enzyme−Intermediate, and Enzyme−Product Complexes of Thiamin Phosphate Synthase † , ‡ journal August 2001
Biosynthesis of 2-methylbacteriohopanepolyols by an anoxygenic phototroph journal September 2007
Cofactor biosynthesis: an organic chemist's treasure trove journal January 2006
Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydAΔEFG journal April 2010
Molybdopterin Biosynthesis: Trapping an Unusual Purine Ribose Adduct in the MoaA-Catalyzed Reaction journal July 2013
Observation of a Second Substrate Radical Intermediate in the Reaction of Lysine 2,3-Aminomutase: A Radical Centered on the .beta.-Carbon of the Alternative Substrate, 4-Thia-L-lysine journal August 1995
MiaB Protein Is a Bifunctional Radical-S-Adenosylmethionine Enzyme Involved in Thiolation and Methylation of tRNA journal November 2004
Enzymatic Modification of tRNAs journal April 2002
The derivation of the oxygen atoms of the 131-oxo and 3-acetyl groups of bacteriochlorophyll a from water in Rhodobacter sphaeroides cells adapting from respiratory to photosynthetic conditions: evidence for an anaerobic pathway for the formation of isocy journal August 1995
S-ADENOSYLMETHIONINE; A NEW INTERMEDIATE FORMED ENZYMATICALLY FROM l-METHIONINE AND ADENOSINETRIPHOSPHATE journal September 1953
S K-edge XAS and DFT Calculations on SAM Dependent Pyruvate Formate-Lyase Activating Enzyme: Nature of Interaction between the Fe 4 S 4 Cluster and SAM and its Role in Reactivity journal November 2011
Thiamine Biosynthesis in Escherichia coli journal February 2004
Electron transfer in nitrogenase catalysis journal April 2012
A pAO1-encoded molybdopterin cofactor gene (moaA) ofArthrobacter nicotinovorans: characterization and site-directed mutagenesis of the encoded protein journal August 1995
Investigations of the biogenesis of chlorophyll a journal January 1969
Lipoic acid metabolism in Escherichia coli: isolation of null mutants defective in lipoic acid biosynthesis, molecular cloning and characterization of the E. coli lip locus, and identification of the lipoylated protein of the glycine cleavage system. journal January 1991
Characterization of Chlorobium tepidum Chlorosomes: A Calculation of Bacteriochlorophyll c per Chlorosome and Oligomer Modeling journal October 2003
A possible glycine radical in anaerobic ribonucleotide reductase from Escherichia coli: nucleotide sequence of the cloned nrdD gene. journal January 1993
ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products. journal November 1980
The prosthetic group of a chromoprotein from mycobacteria journal January 1960
Coordination of Adenosylmethionine to a Unique Iron Site of the [4Fe-4S] of Pyruvate Formate-Lyase Activating Enzyme:  A Mössbauer Spectroscopic Study
  • Krebs, Carsten; Broderick, William E.; Henshaw, Timothy F.
  • Journal of the American Chemical Society, Vol. 124, Issue 6, p. 912-913 https://doi.org/10.1021/ja017562i
journal February 2002
Structural Basis for a Kolbe-Type Decarboxylation Catalyzed by a Glycyl Radical Enzyme journal September 2011
Generation of the Glycyl Radical of the Anaerobic Escherichia coli Ribonucleotide Reductase Requires a Specific Activating Enzyme journal February 1995
The Crystal Structure of [Fe]-Hydrogenase Reveals the Geometry of the Active Site journal July 2008
Synthesis and Characterization of 3‘,4‘-Anhydroadenosylcobalamin:  A Coenzyme B 12 Analogue with Unusual Properties journal September 2000
Biosynthesis of pyrrolopyrimidines journal August 2012
Evaluation of biosynthetic pathways for the unique dithiolate ligand of the FeFe hydrogenase H-cluster journal September 2010
Evidence for acyl–iron ligation in the active site of [Fe]-hydrogenase provided by mass spectrometry and infrared spectroscopy journal January 2012
Identification of a Plasmid-Borne Chloramphenicol-Florfenicol Resistance Gene inStaphylococcus sciuri journal September 2000
NirF is a periplasmic protein that binds d1 heme as part of its essential role in d1 heme biogenesis: Periplasmic NirF binds d1 heme journal November 2010
The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine journal February 2006
Specific Roles of Methylcobamide:Coenzyme M Methyltransferase Isozymes in Metabolism of Methanol and Methylamines in Methanosarcina barkeri journal March 1996
Biosynthesis of the modified peptide antibiotic nosiheptide in Streptomyces actuosus journal August 1993
Three-iron clusters in iron-sulfur proteins journal April 1983
Product inhibition in the radical S -adenosylmethionine family journal March 2009
Biosynthesis of lipoic acid: Characterization of the lipoic acid auxotrophs Escherichia coli W1485-lip2 and JRG33-lip9 journal April 1993
Radical-mediated enzymatic carbon chain fragmentation-recombination journal January 2011
Biosynthesis of lipoic acid. 2. Stereochemistry of sulfur introduction at C-6 of octanoic acid journal August 1978
Probing the Unusual Oxidation/Reduction Behavior of Paracoccus pantotrophus Cytochrome cd 1 Nitrite Reductase by Replacing a Switchable Methionine Heme Iron Ligand with Histidine † journal September 2006
Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor journal November 2011
Activation of Class III Ribonucleotide Reductase by Flavodoxin:  A Protein Radical-Driven Electron Transfer to the Iron−Sulfur Center journal March 2001
The Structural and Biochemical Foundations of Thiamin Biosynthesis journal June 2009
A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency journal July 1995
Nitrogen Fixation: The Mechanism of the Mo-Dependent Nitrogenase journal January 2003
S -Adenosylmethionine:  A Wolf in Sheep's Clothing, or a Rich Man's Adenosylcobalamin? journal June 2003
Molecular Basis for Multiple Sulfatase Deficiency and Mechanism for Formylglycine Generation of the Human Formylglycine-Generating Enzyme journal May 2005
Phenotypic evidence that the function of the [Fe]-hydrogenase Hmd in Methanococcus maripaludis requires seven hcg ( hmd co-occurring genes) but not hmdII journal April 2013
A Radical Intermediate in Tyrosine Scission to the CO and CN- Ligands of FeFe Hydrogenase journal October 2013
Synthesis of pyrroloquinoline quinone in vivo and in vitro and detection of an intermediate in the biosynthetic pathway. journal September 1995
Spore Photoproduct Lyase from Bacillus subtilis Spores Is a Novel Iron-Sulfur DNA Repair Enzyme Which Shares Features with Proteins such as Class III Anaerobic Ribonucleotide Reductases and Pyruvate-Formate Lyases journal September 1998
Biosynthesis of pyrroloquinoline quinone. 1. Identification of biosynthetic precursors using carbon-13 labeling and NMR spectroscopy journal September 1988
Mutational Analysis of the sbo-alb Locus of Bacillus subtilis: Identification of Genes Required for Subtilosin Production and Immunity journal June 2000
Biosynthesis of lipoic acid: extent of incorporation of deuterated hydroxy- and thiooctanoic acids into lipoic acid journal October 1980
Spectroscopic, Steady-State Kinetic, and Mechanistic Characterization of the Radical SAM Enzyme QueE, Which Catalyzes a Complex Cyclization Reaction in the Biosynthesis of 7-Deazapurines journal December 2012
Interaction between DNA and alpha/beta-type small, acid-soluble spore proteins: a new class of DNA-binding protein. journal January 1992
Stoichiometry of the Redox Neutral Deamination and Oxidative Dehydrogenation Reactions Catalyzed by the Radical SAM Enzyme DesII journal February 2010
A role for the elongator complex in zygotic paternal genome demethylation journal January 2010
Biotin Synthase from Escherichiacoli, an Investigation of the Low Molecular Weight and Protein Components Required for Activity inVitro journal August 1995
Tyrosine, Cysteine, and S-Adenosyl Methionine Stimulate In Vitro [FeFe] Hydrogenase Activation journal October 2009
14N HYSCORE investigation of the H-cluster of [FeFe] hydrogenase: evidence for a nitrogen in the dithiol bridge journal January 2009
Characterization of the Cofactor Composition of Escherichia coli Biotin Synthase † journal February 2004
The Radical SAM Superfamily journal January 2008
Oxygen-independent Coproporphyrinogen-III Oxidase HemN from Escherichia coli journal July 2002
The biosynthesis of lipoic acid. Cloning of lip, a lipoate biosynthetic locus of Escherichia coli. journal May 1992
Molecular cloning and characterization of the Bacillus subtilis spore photoproduct lyase (spl) gene, which is involved in repair of UV radiation-induced DNA damage during spore germination. journal January 1993
Characterization of the DNA repair spore photoproduct lyase enzyme from Clostridium acetobutylicum: A radical-SAM enzyme journal August 2007
C-methylation occurs during the biosynthesis of heme d1. journal August 1990
Activation of the Anaerobic Ribonucleotide Reductase fromEscherichia coli journal September 1997
Oxygen-sensitive ribonucleoside triphosphate reductase is present in anaerobic Escherichia coli. journal April 1989
An iron-dependent modification of several transfer RNA species in Escherichia coli journal December 1969
X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification journal May 2013
Lipoic Acid Biosynthesis:  LipA Is an Iron−Sulfur Protein journal May 1999
Spectroscopic Changes during a Single Turnover of Biotin Synthase:  Destruction of a [2Fe-2S] Cluster Accompanies Sulfur Insertion † journal July 2001
The iron-sulfur center of biotin synthase: site-directed mutants journal July 2001
Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA journal April 2006
Structural characterization of a molybdopterin precursor journal June 1993
The chemistry of dammar resin journal January 1955
Role of the [2Fe−2S] Cluster in Recombinant Escherichia coli Biotin Synthase † journal February 2004
Lipoic acid metabolism in Escherichia coli: the lplA and lipB genes define redundant pathways for ligation of lipoyl groups to apoprotein. journal January 1995
New Insights into [FeFe] Hydrogenase Activation and Maturase Function journal September 2012
Iron-sulfur proteins: ancient structures, still full of surprises journal February 2000
Synthesis of the spore photoproduct journal February 1997
NifX and NifEN exchange NifB cofactor and the VK-cluster, a newly isolated intermediate of the iron-molybdenum cofactor biosynthetic pathway journal January 2007
Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycinbiosynthesis and affording a novel bleomycin analog journal January 2010
The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine journal March 2011
Human Coproporphyrinogen Oxidase Is Not a Metalloprotein journal December 1996
Nucleotide sequences of two serine tRNAs with a GGA anticodon: the structure-function relationships in the serine family of E. coli tRNAs journal January 1985
9-Mercaptodethiobiotin Is Generated as a Ligand to the [2Fe–2S] + Cluster during the Reaction Catalyzed by Biotin Synthase from Escherichia coli journal May 2012
The 3D Structure of Thuricin CD, a Two-Component Bacteriocin with Cysteine Sulfur to α-Carbon Cross-links journal May 2011
Sequence analysis of an internal 9.72-kb segment from the 30-kb denitrification gene cluster of Pseudomonas stutzeri journal November 1996
The sulfatase gene family journal June 1997
A “Radical Dance” in Thiamin Biosynthesis: Mechanistic Analysis of the Bacterial Hydroxymethylpyrimidine Phosphate Synthase journal September 2010
A New UAG-Encoded Residue in the Structure of a Methanogen Methyltransferase journal May 2002
Combined NMR and DFT Studies for the Absolute Configuration Elucidation of the Spore Photoproduct, a UV-Induced DNA Lesion journal December 2008
A novel lysine 2,3-aminomutase encoded by the yodO gene of Bacillus subtilis: characterization and the observation of organic radical intermediates journal June 2000
Analysis of the Cob(II)alamin−5‘-Deoxy-3‘,4‘-anhydroadenosyl Radical Triplet Spin System in the Active Site of Diol Dehydrase † journal December 2006
Reduction of the [2Fe–2S] Cluster Accompanies Formation of the Intermediate 9-Mercaptodethiobiotin in Escherichia coli Biotin Synthase journal September 2011
Complex Biotransformations Catalyzed by Radical S -Adenosylmethionine Enzymes journal July 2011
ms2i6A deficiency enhances proofreading in translation journal December 1991
Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme journal November 2012
Biosynthesis of the Iron-Guanylylpyridinol Cofactor of [Fe]-Hydrogenase in Methanogenic Archaea as Elucidated by Stable-Isotope Labeling journal February 2012
The Electronic Structure of the H-Cluster in the [FeFe]-Hydrogenase from Desulfovibrio desulfuricans : A Q-band 57 Fe-ENDOR and HYSCORE Study journal September 2007
Study of C-4 Deoxygenation in the Biosynthesis of Desosamine:  Evidence Implicating a Novel Mechanism journal August 2001
Structural insights into a protein-bound iron-molybdenum cofactor precursor journal January 2006
Mutational Analysis of ThiH, a Member of the Radical S-Adenosylmethionine (AdoMet) Protein Superfamily journal September 2004
The Presence of the Iron-Sulfur Motif Is Important for the Conformational Stability of the Antiviral Protein, Viperin journal February 2012
X-ray Crystal Structure of the Fe-Only Hydrogenase (CpI) from Clostridium pasteurianum to 1.8 Angstrom Resolution journal December 1998
TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes journal April 2001
Lysine 2,3-Aminomutase journal January 1989
EPR-kinetic isotope effect study of the mechanism of radical-mediated dehydrogenation of an alcohol by the radical SAM enzyme DesII journal January 2013
Cloning, sequencing and regulation of thiA, a thiamin biosynthesis gene from Bacillus subtilis journal October 1997
The N-terminal Amphipathic α-Helix of Viperin Mediates Localization to the Cytosolic Face of the Endoplasmic Reticulum and Inhibits Protein Secretion journal December 2008
The catalytic mechanism for aerobic formation of methane by bacteria journal April 2013
Pyrrolysine Encoded by UAG in Archaea: Charging of a UAG-Decoding Specialized tRNA journal May 2002
4-Hydroxyphenylacetate decarboxylase activating enzyme catalyses a classical S-adenosylmethionine reductive cleavage reaction journal May 2013
Biotin Synthase Exhibits Burst Kinetics and Multiple Turnovers in the Absence of Inhibition by Products and Product-Related Biomolecules journal November 2010
Nitrate respiration in relation to facultative metabolism in enterobacteria journal June 1988
Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework journal August 2009
Cysteine Methylation Controls Radical Generation in the Cfr Radical AdoMet rRNA Methyltransferase journal July 2013
Analysis of ThiC Variants in the Context of the Metabolic Network of Salmonella enterica journal September 2012
Biosynthesis of the 3-Acetyl and 131-Oxo Groups of Bacteriochlorophyll a in the Facultative Aerobic Bacterium, Rhodovulum sulfidophilum . The presence of both oxygenase and hydratase pathways for isocyclic ring formation journal October 1998
In silico evaluation of proposed biosynthetic pathways for the unique dithiolate ligand of the H-cluster of [FeFe]-hydrogenase journal August 2011
Lesions in gshA (Encoding γ-l-Glutamyl-l-Cysteine Synthetase) Prevent Aerobic Synthesis of Thiamine in Salmonella enterica Serovar Typhimurium LT2 journal September 2000
Biochemical Analysis of the Interactions between the Proteins Involved in the [FeFe]-Hydrogenase Maturation Process journal August 2012
Thiamine biosynthesis in Escherichia coli : isolation and initial characterisation of the ThiGH complex journal March 2003
Pyruvate Formate-lyase, Evidence for an Open Conformation Favored in the Presence of Its Activating Enzyme journal June 2010
Lysine 2,3-Aminomutase from Clostridium subterminale SB4: Mass Spectral Characterization of Cyanogen Bromide-Treated Peptides and Cloning, Sequencing, and Expression of the Gene kamA in Escherichia coli journal January 2000
Cofactor Dependence of Reduction Potentials for [4Fe-4S] 2+/1+ in Lysine 2,3-Aminomutase † journal March 2006
MoaA of Arthrobacter nicotinovorans pAO1 involved in Mo-Pterin cofactor synthesis is an Fe-S protein journal August 1996
Role of the [2Fe-2S] 2+ Cluster in Biotin Synthase:  Mutagenesis of the Atypical Metal Ligand Arginine 260 † journal November 2006
Reconstitution and Characterization of the Polynuclear Iron-Sulfur Cluster in Pyruvate Formate-lyase-activating Enzyme: MOLECULAR PROPERTIES OF THE HOLOENZYME FORM journal February 1998
The [FeFe]-hydrogenase maturase HydF from Clostridium acetobutylicum contains a CO and CN − ligated iron cofactor journal December 2009
[FeFe]-Hydrogenase Cyanide Ligands Derived From S-Adenosylmethionine-Dependent Cleavage of Tyrosine journal January 2010
The biosyntheticgene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892 journal January 2009
Anaerobic sulfatase-maturating enzyme - A mechanistic link with glycyl radical-activating enzymes?: Mechanistic investigations of anSME journal March 2010
Assembly of the Covalent Linkage between Lipoic Acid and Its Cognate Enzymes journal December 2003
Characterization and Mechanistic Study of a Radical SAM Dehydrogenase in the Biosynthesis of Butirosin journal December 2007
Genetic Analysis of the Methanol- and Methylamine-Specific Methyltransferase 2 Genes of Methanosarcina acetivorans C2A journal March 2008
Molecular properties of lysine-2,3-aminomutase. journal April 1991
Crystal Structure of the NAD Biosynthetic Enzyme Quinolinate Synthase journal July 2005
Identification of Lysine 346 as a Functionally Important Residue for Pyridoxal 5‘-Phosphate Binding and Catalysis in Lysine 2,3-Aminomutase from Bacillus subtilis † journal January 2001
Biosynthesis of lipoic acid. 1. Incorporation of specifically tritiated octanoic acid into lipoic acid journal September 1977
Genes Involved in Formation and Attachment of a Two-Carbon Chain as a Component of Eurekanate, a Branched-Chain Sugar Moiety of Avilamycin A journal January 2005
[2Fe-2S] to [4Fe-4S] Cluster Conversion in Escherichia coli Biotin Synthase † journal September 1997
Proposed structure for coenzyme F 420 from methanobacterium journal October 1978
The [4Fe-4S] 1+ Cluster of Pyruvate Formate-Lyase Activating Enzyme Generates the Glycyl Radical on Pyruvate Formate-Lyase:  EPR-Detected Single Turnover journal August 2000
Structural Insights into Radical Generation by the Radical SAM Superfamily journal March 2011
NifEN-B complex of Azotobacter vinelandii is fully functional in nitrogenase FeMo cofactor assembly journal May 2011
Complete stereospecific repair of a synthetic dinucleotide spore photoproduct by spore photoproduct lyase journal April 2010
Regioselectivity in the Homolytic Cleavage of S-Adenosylmethionine journal December 2010
Ribonucleotide reductases: the link between an RNA and a DNA world? journal December 2000
Structural rearrangements of the ribosome at the tRNA proofreading step journal August 2010
Analysis of spore photoproduct lyase operon (splAB ) function using targeted deletion-insertion mutations spanning the Bacillus subtilis operons ptsHI and splAB journal August 1997
Iron−Sulfur Cluster Interconversions in Biotin Synthase:  Dissociation and Reassociation of Iron during Conversion of [2Fe-2S] to [4Fe-4S] Clusters † journal May 2000
Glutamate 2,3-aminomutase: A new member of the radical SAM superfamily of enzymes journal February 2007
Coproporphyrinogenase activity in extracts from rhodopseudomonas spheroides journal September 1969
Biosynthesis of the 22nd Genetically Encoded Amino Acid Pyrrolysine: Structure and Reaction Mechanism of PylC at 1.5Å Resolution journal December 2012
Biotin Synthase Mechanism: Evidence for Hydrogen Transfer from the Substrate into Deoxyadenosine journal April 1999
High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana journal December 2013
Subunit Structure of Benzylsuccinate Synthase † journal February 2009
Characterization of MOCS1A, an Oxygen-sensitive Iron-Sulfur Protein Involved in Human Molybdenum Cofactor Biosynthesis journal June 2004
The anaerobic ribonucleoside triphosphate reductase from Escherichia coli requires S-adenosylmethionine as a cofactor. journal May 1990
Molecular properties of pyruvate formate-lyase activating enzyme journal December 1993
Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction journal January 2004
Isolation and first EPR characterization of the [FeFe]-hydrogenases from green algae journal May 2008
Adenosylmethionine-dependent iron-sulfur enzymes: versatile clusters in a radical new role journal March 2001
A New Type of Bacterial Sulfatase Reveals a Novel Maturation Pathway in Prokaryotes journal August 2006
Iron-sulfur cluster coordination in the [FeFe]-hydrogenase H cluster biosynthetic factor HydF journal October 2012
Cell-free H-cluster Synthesis and [FeFe] Hydrogenase Activation: All Five CO and CN− Ligands Derive from Tyrosine journal May 2011
Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme journal October 2008
The [4Fe−4S] 2+ Cluster in Reconstituted Biotin Synthase Binds S -Adenosyl- l -methionine journal November 2002
Radical SAM enzymes in the biosynthesis of sugar-containing natural products journal November 2012
Regulation of the synthesis of H 2 -forming methylenetetrahydromethanopterin dehydrogenase (Hmd) and of HmdII and HmdIII in Methanothermobacter marburgensis journal September 2000
Identification of a nitrogenase FeMo cofactor precursor on NifEN complex journal February 2005
Reactivity and Chemical Synthesis of L-Pyrrolysine— the 22nd Genetically Encoded Amino Acid journal September 2004
Chemical model for the pyridoxal 5'-phosphate dependent lysine aminomutases journal November 1990
The Deazapurine Biosynthetic Pathway Revealed: In Vitro Enzymatic Synthesis of PreQ 0 from Guanosine 5′-Triphosphate in Four Steps journal May 2009
Thiostrepton Biosynthesis: Prototype for a New Family of Bacteriocins journal April 2009
Binding Energy in the One-Electron Reductive Cleavage of S -Adenosylmethionine in Lysine 2,3-Aminomutase, a Radical SAM Enzyme † journal November 2007
Characterization of an Allylic Analogue of the 5‘-Deoxyadenosyl Radical: An Intermediate in the Reaction of Lysine 2,3-Aminomutase † journal July 2001
Functional context, biosynthesis, and genetic encoding of pyrrolysine journal June 2011
Molybdenum Cofactor Biosynthesis and Molybdenum Enzymes journal June 2006
Flavodoxin cofactor binding induces structural changes that are required for protein–protein interactions with NADP+ oxidoreductase and pyruvate formate-lyase activating enzyme journal December 2013
Occurrence, biosynthesis and function of isoprenoid quinones journal September 2010
Ribosome Biogenesis and the Translation Process in Escherichia coli journal September 2007
The Substrate Radical of Escherichia coli Oxygen-independent Coproporphyrinogen III Oxidase HemN journal June 2006
Studies on the mechanism of lysine 2,3-aminomutase journal January 1988
Proposed nomenclature for the genes involved in molybdenum metabolism in Escherichia coli and Saimonella typhimurium journal November 1992
In Vitro Characterization of AtsB, a Radical SAM Formylglycine-Generating Enzyme That Contains Three [4Fe-4S] Clusters † journal July 2008
ENDOR Spectroscopy Shows That Guanine N1 Binds to [4Fe−4S] Cluster II of the S -Adenosylmethionine-Dependent Enzyme MoaA: Mechanistic Implications journal July 2009
Emerging Paradigms for Complex Iron-Sulfur Cofactor Assembly and Insertion journal July 2012
S-adenosyl-l-methionine, a component of the clastic dissimilation of pyruvate in Escherichia coli journal October 1965
Reduced Flux through the Purine Biosynthetic Pathway Results in an Increased Requirement for Coenzyme A in Thiamine Synthesis in Salmonella enterica Serovar Typhimurium journal January 2000
Unexpected electron transfer mechanism upon AdoMet cleavage in radical SAM proteins journal August 2009
Structure of a Cofactor-Deficient Nitrogenase MoFe Protein journal April 2002
HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis journal May 2008
Biosynthetic studies of substituent homologation in bacteriochlorophylls c and d journal May 1990
Metal cofactors of lysine-2,3-aminomutase. journal April 1991
X-ray Structure of Pyruvate Formate-Lyase in Complex with Pyruvate and CoA journal October 2002
Evidence for the Monomerization of Spore Photoproduct to two Thymines by the Light-Independent "Spore Repair" Process in Bacillus Subtilis journal January 1977
Biosynthesis of the modified peptide antibiotic nosiheptide in Streptomyces actuosus journal August 1988
The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics journal January 2007
A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503: Drug resistance by methylation of A2503 in 23S rRNA journal July 2005
The [4Fe–4S]-cluster coordination of [FeFe]-hydrogenase maturation protein HydF as revealed by EPR and HYSCORE spectroscopies journal December 2012
Cyanide and Carbon Monoxide Ligand Formation in Hydrogenase Biosynthesis journal January 2011
Escherichia coli Dimethylallyl Diphosphate:tRNA Dimethylallyltransferase:  Essential Elements for Recognition of tRNA Substrates Within the Anticodon Stem−Loop † journal May 2000
Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis journal November 2011
Fate of the (2Fe-2S) 2+ Cluster of Escherichia coli Biotin Synthase during Reaction: A Mössbauer Characterization † journal July 2003
Escherichia coli Biotin Synthase Produces Selenobiotin. Further Evidence of the Involvement of the [2Fe-2S] 2+ Cluster in the Sulfur Insertion Step † journal March 2006
Biotin Synthase Mechanism:  Mutagenesis of the YNHNLD Conserved Motif † , ‡ journal October 2006
The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A journal October 2011
Biosynthesis of F 0 , Precursor of the F 420 Cofactor, Requires a Unique Two Radical-SAM Domain Enzyme and Tyrosine as Substrate journal October 2012
Stable isotope studies on the biosynthesis of lipoic acid in Escherichia coli journal January 1980
The respiratory chain of Helicobacter pylori : identification of cytochromes and the effects of oxygen on cytochrome and menaquinone levels journal April 1996
Cfr and RlmN Contain a Single [4Fe-4S] Cluster, which Directs Two Distinct Reactivities for S -Adenosylmethionine: Methyl Transfer by S N 2 Displacement and Radical Generation journal December 2011
NifB-dependent in vitro synthesis of the iron-molybdenum cofactor of nitrogenase journal March 2006
Acinetobacter calcoaceticus genes involved in biosynthesis of the coenzyme pyrrolo-quinoline-quinone: nucleotide sequence and expression in Escherichia coli K-12. journal January 1989
Identification and Functional Characterization of the Protein controlled by the Streptomycin-resistant Locus in E. coli journal April 1969
Post-translational Formylglycine Modification of Bacterial Sulfatases by the Radical S-Adenosylmethionine Protein AtsB journal April 2004
Biotin Synthase: Purification, Characterization as a [2Fe-2S]Cluster Protein, and in vitro Activity of the Escherichia coli bioB Gene Product journal March 1994
Structure of Subtilosin A, a Cyclic Antimicrobial Peptide from Bacillus subtilis with Unusual Sulfur to α-Carbon Cross-Links:  Formation and Reduction of α-Thio-α-Amino Acid Derivatives † , ‡ journal March 2004
Effects of the Binding of α/β-type Small, Acid-soluble Spore Proteins on the Photochemistry of DNA in Spores of Bacillus subtilis and In Vitro¶ journal January 2005
S -Adenosylmethionine-Dependent Reduction of Lysine 2,3-Aminomutase and Observation of the Catalytically Functional Iron−Sulfur Centers by Electron Paramagnetic Resonance † journal February 1998
Structure and mechanism of iron-only hydrogenases journal December 1999

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