skip to main content

Title: Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic

We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design.
Authors:
 [1] ;  [2] ;  [1] ;  [3] ;  [3] ;  [2] ;  [1]
  1. Univ. of South Florida, Tampa, FL (United States). Dept. of PMolecular Medicine
  2. Univ. of Lodz (Poland). Dept. of Organic Chemistry
  3. National Inst. of Public Health - National Inst. of Hygiene (NIPH-NIH), Warsaw (Poland)
Publication Date:
OSTI Identifier:
1178850
Grant/Contract Number:
W-31-109-Eng-38; DEC-2013/11/B/ST5/00997
Type:
Accepted Manuscript
Journal Name:
ChemComm
Additional Journal Information:
Journal Volume: 51; Journal Issue: 28; Journal ID: ISSN 1359-7345
Publisher:
Royal Society of Chemistry
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org:
National Institutes of Health (NIH); USDOE
Country of Publication:
United States
Language:
ENGLISH
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES