Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

Parker, Matthew W.; Linkugel, Andrew D.; Goel, Hira Lal; Wu, Tingting; Mercurio, Arthur M.; Vander Kooi, Craig W.

doi:10.1016/j.str.2015.01.018

Title: Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

Journal Article · Wed Jul 01 00:00:00 EDT 2015 · Structure

DOI:https://doi.org/10.1016/j.str.2015.01.018· OSTI ID:1178841

Parker, Matthew W.; Linkugel, Andrew D.; Goel, Hira Lal; Wu, Tingting; Mercurio, Arthur M.; Vander Kooi, Craig W. ^[1]

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DODNIH

OSTI ID:: 1178841

Journal Information:: Structure, Vol. 23, Issue (4) ; 04, 2015

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 39 works

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References (69)

Structure and function of VEGF receptors Stuttfeld, Edward; Ballmer-Hofer, Kurt IUBMB Life, Vol. 61, Issue 9 https://doi.org/10.1002/iub.234	journal	September 2009
Refinement of Macromolecular Structures by the Maximum-Likelihood Method Murshudov, G. N.; Vagin, A. A.; Dodson, E. J. Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3 https://doi.org/10.1107/S0907444996012255	journal	May 1997
Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes Tennessen, Jacob A.; Bigham, Abigail W.; O’Connor, Timothy D. Science, Vol. 337, Issue 6090 https://doi.org/10.1126/science.1219240	journal	May 2012
Genomic Organization of Human Neuropilin-1 and Neuropilin-2 Genes: Identification and Distribution of Splice Variants and Soluble Isoforms Rossignol, Mireille; Gagnon, Michael L.; Klagsbrun, Michael Genomics, Vol. 70, Issue 2 https://doi.org/10.1006/geno.2000.6381	journal	December 2000
Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors Karpanen, Terhi; Heckman, Caroline A.; Keskitalo, Salla The FASEB Journal, Vol. 20, Issue 9 https://doi.org/10.1096/fj.05-5646com	journal	July 2006
Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1* Parker, Matthew W.; Xu, Ping; Li, Xiaobo Journal of Biological Chemistry, Vol. 287, Issue 14 https://doi.org/10.1074/jbc.M111.331140	journal	March 2012
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Appleton, Brent A.; Wu, Ping; Maloney, Janice The EMBO Journal, Vol. 26, Issue 23 https://doi.org/10.1038/sj.emboj.7601906	journal	November 2007
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation Leppanen, V. -M.; Tvorogov, D.; Kisko, K. Proceedings of the National Academy of Sciences, Vol. 110, Issue 32 https://doi.org/10.1073/pnas.1301415110	journal	July 2013
Function of Members of the Neuropilin Family as Essential Pleiotropic Cell Surface Receptors Parker, Matthew W.; Guo, Hou-Fu; Li, Xiaobo Biochemistry, Vol. 51, Issue 47 https://doi.org/10.1021/bi3012143	journal	November 2012
Lymphatic and Angiogenic Candidate Genes Predict the Development of Secondary Lymphedema following Breast Cancer Surgery Miaskowski, Christine; Dodd, Marylin; Paul, Steven M. PLoS ONE, Vol. 8, Issue 4 https://doi.org/10.1371/journal.pone.0060164	journal	April 2013
Zebrafish ProVEGF-C Expression, Proteolytic Processing and Inhibitory Effect of Unprocessed ProVEGF-C during Fin Regeneration Khatib, Abdel-Majid; Lahlil, Rachid; Scamuffa, Nathalie PLoS ONE, Vol. 5, Issue 7 https://doi.org/10.1371/journal.pone.0011438	journal	July 2010
The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing Adams, R. H. The EMBO Journal, Vol. 16, Issue 20 https://doi.org/10.1093/emboj/16.20.6077	journal	October 1997
VEGF-Trap: A VEGF blocker with potent antitumor effects Holash, J.; Davis, S.; Papadopoulos, N. Proceedings of the National Academy of Sciences, Vol. 99, Issue 17 https://doi.org/10.1073/pnas.172398299	journal	August 2002
Wet and dry interfaces: the role of solvent in protein–protein and protein–DNA recognition Janin, Joël Structure, Vol. 7, Issue 12 https://doi.org/10.1016/S0969-2126(00)88333-1	journal	January 1999
Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1 Makinen, Taija; Olofsson, Birgitta; Karpanen, Terhi Journal of Biological Chemistry, Vol. 274, Issue 30 https://doi.org/10.1074/jbc.274.30.21217	journal	July 1999
Aflibercept (VEGF Trap-eye): the newest anti-VEGF drug Stewart, Michael W. British Journal of Ophthalmology, Vol. 96, Issue 9 https://doi.org/10.1136/bjophthalmol-2011-300654	journal	March 2012
Soluble receptors for cytokines and growth factors: generation and biological function Rose-John, S.; Heinrich, P. C. Biochemical Journal, Vol. 300, Issue 2 https://doi.org/10.1042/bj3000281	journal	June 1994
Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor Soker, Shay; Takashima, Seiji; Miao, Hua Quan Cell, Vol. 92, Issue 6 https://doi.org/10.1016/s0092-8674(00)81402-6	journal	March 1998
Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration Favier, Benoit; Alam, Antoine; Barron, Pauline Blood, Vol. 108, Issue 4 https://doi.org/10.1182/blood-2005-11-4447	journal	August 2006
A model for gene therapy of human hereditary lymphedema Karkkainen, M. J.; Saaristo, A.; Jussila, L. Proceedings of the National Academy of Sciences, Vol. 98, Issue 22 https://doi.org/10.1073/pnas.221449198	journal	October 2001
Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos Haiko, Paula; Makinen, Taija; Keskitalo, Salla Molecular and Cellular Biology, Vol. 28, Issue 15 https://doi.org/10.1128/mcb.02214-07	journal	June 2008
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema Karkkainen, Marika J.; Ferrell, Robert E.; Lawrence, Elizabeth C. Nature Genetics, Vol. 25, Issue 2 https://doi.org/10.1038/75997	journal	June 2000
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis Siegfried, Geraldine; Basak, Ajoy; Cromlish, James A. Journal of Clinical Investigation, Vol. 111, Issue 11 https://doi.org/10.1172/JCI200317220	journal	June 2003
Vascular Endothelial Growth Factor (VEGF) and VEGF-C Show Overlapping Binding Sites in Embryonic Endothelia and Distinct Sites in Differentiated Adult Endothelia Lymboussaki, Athina; Olofsson, Birgitta; Eriksson, Ulf Circulation Research, Vol. 85, Issue 11 https://doi.org/10.1161/01.RES.85.11.992	journal	November 1999
Corneal avascularity is due to soluble VEGF receptor-1 Ambati, Balamurali K.; Nozaki, Miho; Singh, Nirbhai Nature, Vol. 443, Issue 7114 https://doi.org/10.1038/nature05249	journal	October 2006
Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III He, Zhigang; Tessier-Lavigne, Marc Cell, Vol. 90, Issue 4 https://doi.org/10.1016/s0092-8674(00)80534-6	journal	August 1997
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. Joukov, V.; Pajusola, K.; Kaipainen, A. The EMBO Journal, Vol. 15, Issue 7 https://doi.org/10.1002/j.1460-2075.1996.tb00521.x	journal	April 1996
Autophagy Control by the VEGF-C/NRP-2 Axis in Cancer and Its Implication for Treatment Resistance Stanton, Marissa J.; Dutta, Samikshan; Zhang, Heyu Cancer Research, Vol. 73, Issue 1 https://doi.org/10.1158/0008-5472.CAN-11-3635	journal	November 2012
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth Albuquerque, Romulo J. C.; Hayashi, Takahiko; Cho, Won Gil Nature Medicine, Vol. 15, Issue 9 https://doi.org/10.1038/nm.2018	journal	August 2009
Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D McColl, Bradley K.; Baldwin, Megan E.; Roufail, Sally Journal of Experimental Medicine, Vol. 198, Issue 6 https://doi.org/10.1084/jem.20030361	journal	September 2003
Genomic Organization of the Mouse and Human Genes for Vascular Endothelial Growth Factor B (VEGF-B) and Characterization of a Second Splice Isoform Olofsson, Birgitta; Pajusola, Katri; von Euler, Gabriel Journal of Biological Chemistry, Vol. 271, Issue 32 https://doi.org/10.1074/jbc.271.32.19310	journal	August 1996
Candidate Gene Analysis in Primary Lymphedema Ferrell, Robert E.; Kimak, Mark A.; Lawrence, Elizabeth C. Lymphatic Research and Biology, Vol. 6, Issue 2 https://doi.org/10.1089/lrb.2007.1022	journal	June 2008
Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Olofsson, B.; Pajusola, K.; Kaipainen, A. Proceedings of the National Academy of Sciences, Vol. 93, Issue 6 https://doi.org/10.1073/pnas.93.6.2576	journal	March 1996
Structural determinants of growth factor binding and specificity by VEGF receptor 2 Leppanen, V. -M.; Prota, A. E.; Jeltsch, M. Proceedings of the National Academy of Sciences, Vol. 107, Issue 6 https://doi.org/10.1073/pnas.0914318107	journal	January 2010
Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer Cao, Qi; Mani, Ram-Shankar; Ateeq, Bushra Cancer Cell, Vol. 20, Issue 2 https://doi.org/10.1016/j.ccr.2011.06.016	journal	August 2011
Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice Jeltsch, M. Science, Vol. 276, Issue 5317 https://doi.org/10.1126/science.276.5317.1423	journal	May 1997
Insights into the Molecular Pathogenesis and Targeted Treatment of Lymphedema Saaristo, Anne; Karkkainen, Marika J.; Alitalo, Kari Annals of the New York Academy of Sciences, Vol. 979, Issue 1 https://doi.org/10.1111/j.1749-6632.2002.tb04871.x	journal	December 2002
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
Tuftsin Binds Neuropilin-1 through a Sequence Similar to That Encoded by Exon 8 of Vascular Endothelial Growth Factor von Wronski, Mathew A.; Raju, Natarajan; Pillai, Radhakrishna Journal of Biological Chemistry, Vol. 281, Issue 9 https://doi.org/10.1074/jbc.M511941200	journal	March 2006
Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF165 via Its Exon 7-encoded Domain Soker, Shay; Fidder, Herman; Neufeld, Gera Journal of Biological Chemistry, Vol. 271, Issue 10 https://doi.org/10.1074/jbc.271.10.5761	journal	March 1996
Structural basis for ligand and heparin binding to neuropilin B domains Vander Kooi, C. W.; Jusino, M. A.; Perman, B. Proceedings of the National Academy of Sciences, Vol. 104, Issue 15 https://doi.org/10.1073/pnas.0700043104	journal	April 2007
Vascular Endothelial Growth Factor D Is Dispensable for Development of the Lymphatic System Baldwin, Megan E.; Halford, Michael M.; Roufail, Sally Molecular and Cellular Biology, Vol. 25, Issue 6 https://doi.org/10.1128/MCB.25.6.2441-2449.2005	journal	March 2005
Ordered water in macromolecular structure Karplus, P. Andrew; Faerman, Carlos Current Opinion in Structural Biology, Vol. 4, Issue 5 https://doi.org/10.1016/S0959-440X(94)90178-3	journal	October 1994
Lymphangiogenesis and cancer metastasis Stacker, Steven A.; Achen, Marc G.; Jussila, Lotta Nature Reviews Cancer, Vol. 2, Issue 8 https://doi.org/10.1038/nrc863	journal	August 2002
Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition Parker, Matthew W.; Xu, Ping; Guo, Hou-Fu PLoS ONE, Vol. 7, Issue 11 https://doi.org/10.1371/journal.pone.0049177	journal	November 2012
Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3 Xu, Yunling; Yuan, Li; Mak, Judy Journal of Cell Biology, Vol. 188, Issue 1 https://doi.org/10.1083/jcb.200903137	journal	January 2010
Abnormal lymphatic vessel development in neuropilin 2 mutant mice Yuan, Li; Moyon, Delphine; Pardanaud, Luc Development, Vol. 129, Issue 20 https://doi.org/10.1242/dev.129.20.4797	journal	October 2002
GLI1 regulates a novel neuropilin‐2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation Goel, Hira Lal; Pursell, Bryan; Chang, Cheng EMBO Molecular Medicine, Vol. 5, Issue 4 https://doi.org/10.1002/emmm.201202078	journal	February 2013
A time- and cost-efficient system for high-level protein production in mammalian cells Aricescu, A. Radu; Lu, Weixian; Jones, E. Yvonne Acta Crystallographica Section D Biological Crystallography, Vol. 62, Issue 10 https://doi.org/10.1107/S0907444906029799	journal	September 2006
Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells Timoshenko, A. V.; Rastogi, S.; Lala, P. K. British Journal of Cancer, Vol. 97, Issue 8 https://doi.org/10.1038/sj.bjc.6603993	journal	October 2007
Vascular Endothelial Growth Factor-C Protects Prostate Cancer Cells from Oxidative Stress by the Activation of Mammalian Target of Rapamycin Complex-2 and AKT-1 Muders, Michael H.; Zhang, Heyu; Wang, Enfeng Cancer Research, Vol. 69, Issue 15 https://doi.org/10.1158/0008-5472.CAN-09-0552	journal	July 2009
The Propeptides of VEGF-D Determine Heparin Binding, Receptor Heterodimerization, and Effects on Tumor Biology* Harris, Nicole C.; Davydova, Natalia; Roufail, Sally Journal of Biological Chemistry, Vol. 288, Issue 12 https://doi.org/10.1074/jbc.m112.439299	journal	March 2013
Proteolytic processing regulates receptor specificity and activity of VEGF-C Joukov, Vladimir; Sorsa, Tarja; Kumar, Vijay The EMBO Journal, Vol. 16, Issue 13 https://doi.org/10.1093/emboj/16.13.3898	journal	July 1997
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis Lohela, Marja; Bry, Maija; Tammela, Tuomas Current Opinion in Cell Biology, Vol. 21, Issue 2 https://doi.org/10.1016/j.ceb.2008.12.012	journal	April 2009
Furin Processing of Semaphorin 3F Determines Its Anti-Angiogenic Activity by Regulating Direct Binding and Competition for Neuropilin Parker, Matthew W.; Hellman, Lance M.; Xu, Ping Biochemistry, Vol. 49, Issue 19 https://doi.org/10.1021/bi100327r	journal	May 2010
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Kendall, R. L.; Thomas, K. A. Proceedings of the National Academy of Sciences, Vol. 90, Issue 22 https://doi.org/10.1073/pnas.90.22.10705	journal	November 1993
Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions Parker, Matthew W.; Vander Kooi, Craig W. Analytical Biochemistry, Vol. 453 https://doi.org/10.1016/j.ab.2014.02.017	journal	May 2014
The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease Holmes, David I. R.; Zachary, Ian Genome Biology, Vol. 6, Issue 2, p. 209 https://doi.org/10.1186/gb-2005-6-2-209	journal	January 2005
The role of neuropilins in cancer Ellis, Lee M. Molecular Cancer Therapeutics, Vol. 5, Issue 5 https://doi.org/10.1158/1535-7163.MCT-05-0538	journal	May 2006
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis Caunt, Maresa; Mak, Judy; Liang, Wei-Ching Cancer Cell, Vol. 13, Issue 4 https://doi.org/10.1016/j.ccr.2008.01.029	journal	April 2008
VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer Goel, Hira Lal; Chang, Cheng; Pursell, Bryan Cancer Discovery, Vol. 2, Issue 10 https://doi.org/10.1158/2159-8290.CD-12-0085	journal	July 2012
Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity Gagnon, M. L.; Bielenberg, D. R.; Gechtman, Z. 'e. Proceedings of the National Academy of Sciences, Vol. 97, Issue 6 https://doi.org/10.1073/pnas.040337597	journal	February 2000
Mutation in Vascular Endothelial Growth Factor-C, a Ligand for Vascular Endothelial Growth Factor Receptor-3, Is Associated With Autosomal Dominant Milroy-Like Primary Lymphedema Gordon, Kristiana; Schulte, Dörte; Brice, Glen Circulation Research, Vol. 112, Issue 6 https://doi.org/10.1161/CIRCRESAHA.113.300350	journal	March 2013
Biosynthesis of Vascular Endothelial Growth Factor-D Involves Proteolytic Processing Which Generates Non-covalent Homodimers Stacker, Steven A.; Stenvers, Kaye; Caesar, Carol Journal of Biological Chemistry, Vol. 274, Issue 45 https://doi.org/10.1074/jbc.274.45.32127	journal	November 1999
Structure–function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF165 binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin-1 complex Starzec, Anna; Ladam, Patrick; Vassy, Roger Peptides, Vol. 28, Issue 12 https://doi.org/10.1016/j.peptides.2007.09.013	journal	December 2007
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins Karkkainen, Marika J.; Haiko, Paula; Sainio, Kirsi Nature Immunology, Vol. 5, Issue 1 https://doi.org/10.1038/ni1013	journal	November 2003
Effect of C-Terminal Sequence on Competitive Semaphorin Binding to Neuropilin-1 Parker, Matthew W.; Linkugel, Andrew D.; Vander Kooi, Craig W. Journal of Molecular Biology, Vol. 425, Issue 22 https://doi.org/10.1016/j.jmb.2013.07.017	journal	November 2013
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development Kukk, Eola; Lymboussaki, Athina; Taira, Suvi Development, Vol. 122, Issue 12 https://doi.org/10.1242/dev.122.12.3829	journal	December 1996

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