Engineering microbes for efficient production of chemicals

Gong, Wei; Dole, Sudhanshu; Grabar, Tammy; Collard, Andrew Christopher; Pero, Janice G; Yocum, R Rogers

Title: Engineering microbes for efficient production of chemicals

Patent · Tue Apr 28 00:00:00 EDT 2015

OSTI ID:1178677

Gong, Wei; Dole, Sudhanshu; Grabar, Tammy; Collard, Andrew Christopher; Pero, Janice G; Yocum, R Rogers

This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic evolution of a bacterial strain genetically engineered to produce succinic acid. This present invention also provides a method for evaluating the industrial applicability of mutations that were selected during the metabolic evolution for increased succinic acid production. This present invention further provides microorganisms engineered to have mutations that are selected during metabolic evolution and contribute to improved production of succinic acid, other organic acids and other chemicals of commercial interest.

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Research Organization:: Myriant Corporation, Quincy, MA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: EE0002878

Assignee:: Myriant Corporation (Quincy, MA)

Patent Number(s):: 9,017,976

Application Number:: 13/503,999

OSTI ID:: 1178677

Resource Relation:: Patent File Date: 2010 Nov 17

Country of Publication:: United States

Language:: English

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