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Title: Challenges for In vitro to in Vivo Extrapolation of Nanomaterial Dosimetry for Human Risk Assessment

The proliferation in types and uses of nanomaterials in consumer products has led to rapid application of conventional in vitro approaches for hazard identification. Unfortunately, assumptions pertaining to experimental design and interpretation for studies with chemicals are not generally appropriate for nanomaterials. The fate of nanomaterials in cell culture media, cellular dose to nanomaterials, cellular dose to nanomaterial byproducts, and intracellular fate of nanomaterials at the target site of toxicity all must be considered in order to accurately extrapolate in vitro results to reliable predictions of human risk.
Authors:
Publication Date:
OSTI Identifier:
1177355
Report Number(s):
PNNL-SA-99026
400412000
DOE Contract Number:
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Gradient EH&S Nano News, 8(3):4
Research Org:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
in vitro; nanotoxicology; nanomaterial