Method and apparatus for multispray emitter for mass spectrometry

Smith, Richard D.; Tang, Keqi; Lin, Yuehe

Title: Method and apparatus for multispray emitter for mass spectrometry

Patent · Tue Dec 14 00:00:00 EST 2004

OSTI ID:1175170

Smith, Richard D.; Tang, Keqi; Lin, Yuehe

A method and apparatus that utilizes two or more emitters simultaneously to form an electrospray of a sample that is then directed into a mass spectrometer, thereby increasing the total ion current introduced into an electrospray ionization mass spectrometer, given a liquid flow rate of a sample. The method and apparatus are most conveniently constructed as an array of spray emitters fabricated on a single chip, however, the present invention encompasses any apparatus wherein two or more emitters are simultaneously utilized to form an electrospray of a sample that is then directed into a mass spectrometer.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC06-76RL01830

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Number(s):: 6,831,274

Application Number:: 10/091,833

OSTI ID:: 1175170

Country of Publication:: United States

Language:: English

References (11)

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Microfluidic Devices Connected to Fused-Silica Capillaries with Minimal Dead Volume Bings, Nicolas H.; Wang, Can; Skinner, Cameron D. Analytical Chemistry, Vol. 71, Issue 15 https://doi.org/10.1021/ac981419z	journal	August 1999
The current emitted by highly conducting Taylor cones De La Mora, J. Fernández; Loscertales, I. G. Journal of Fluid Mechanics, Vol. 260 https://doi.org/10.1017/S0022112094003472	journal	February 1994
Multichannel Microchip Electrospray Mass Spectrometry Xue, Qifeng; Foret, Frantisek; Dunayevskiy, Yuriy M. Analytical Chemistry, Vol. 69, Issue 3 https://doi.org/10.1021/ac9607119	journal	February 1997
A Microfabricated Device for Rapid Protein Identification by Microelectrospray Ion Trap Mass Spectrometry Figeys, Daniel; Ning, Yuebin; Aebersold, Ruedi Analytical Chemistry, Vol. 69, Issue 16 https://doi.org/10.1021/ac970057c	journal	August 1997
A Micromachined Chip-Based Electrospray Source for Mass Spectrometry Licklider, Larry; Wang, Xuan-Qi; Desai, Amish Analytical Chemistry, Vol. 72, Issue 2, p. 367-375 https://doi.org/10.1021/ac990967p	journal	January 2000
Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity Tang, Keqi; Lin, Yuehe; Matson, Dean W. Analytical Chemistry, Vol. 73, Issue 8 https://doi.org/10.1021/ac001191r	journal	April 2001
A Microdevice with Integrated Liquid Junction for Facile Peptide and Protein Analysis by Capillary Electrophoresis/Electrospray Mass Spectrometry Zhang, Bailin; Foret, Frantisek; Karger, Barry L. Analytical Chemistry, Vol. 72, Issue 5 https://doi.org/10.1021/ac991150z	journal	March 2000
Subatmospheric electrospray interface for coupling of microcolumn separations with mass spectrometry Foret, Frantisek; Zhou, Haihong; Gangl, Eric Electrophoresis, Vol. 21, Issue 7, p. 1363-1371 https://doi.org/10.1002/(SICI)1522-2683(20000401)21:7<1363::AID-ELPS1363>3.0.CO;2-U	journal	April 2000
Microfabricated Devices for Capillary Electrophoresis−Electrospray Mass Spectrometry Zhang, B.; Liu, H.; Karger, B. L. Analytical Chemistry, Vol. 71, Issue 15 https://doi.org/10.1021/ac990090u	journal	August 1999
Generating Electrospray from Microchip Devices Using Electroosmotic Pumping Ramsey, R. S.; Ramsey, J. M. Analytical Chemistry, Vol. 69, Issue 6 https://doi.org/10.1021/ac9610671	journal	March 1997

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