Potent and selective mediators of cholesterol efflux

Bielicki, John K; Johansson, Jan

Title: Potent and selective mediators of cholesterol efflux

Patent · Tue Mar 24 00:00:00 EDT 2015

OSTI ID:1174197

Bielicki, John K; Johansson, Jan

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

View Patent

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,987,192

Application Number:: 12/519,116

OSTI ID:: 1174197

Resource Relation:: Patent File Date: 2007 Dec 13

Country of Publication:: United States

Language:: English

References (11)

Characteristics of the amino acids as components of a peptide hormone sequence Rudinger, J.; Parsons, J. A. Peptide Hormones, p. 1-7 https://doi.org/10.1007/978-1-349-02718-7_1	book	January 1976
Protein Folding: A Glimpse of the Holy Grail? Berendsen, H. J. C. Science, Vol. 282, Issue 5389, p. 642-643 https://doi.org/10.1126/science.282.5389.642	journal	October 1998
Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox Ngo, J. Thomas; Marks, Joe; Karplus, Martin The Protein Folding Problem and Tertiary Structure Prediction, p. 433-506 https://doi.org/10.1007/978-1-4684-6831-1_14	book	January 1994
Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat Bradley, Christina Marchetti; Barrick, Doug Journal of Molecular Biology, Vol. 324, Issue 2, p. 373-386 https://doi.org/10.1016/S0022-2836(02)00945-2	journal	November 2002
Sustained-delivery of an apolipoproteinE–peptidomimetic using multivesicular liposomes lowers serum cholesterol levels Ramprasad, Mysore P.; Anantharamaiah, G. M.; Garber, David W. Journal of Controlled Release, Vol. 79, Issue 1-3, p. 207-218 https://doi.org/10.1016/S0168-3659(01)00552-1	journal	February 2002
Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity Song, Yun Mi; Yang, Sung-Tae; Lim, Shin Saeng Biochemical and Biophysical Research Communications, Vol. 314, Issue 2, p. 615-621 https://doi.org/10.1016/j.bbrc.2003.12.142	journal	February 2004
Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus Sparrow, James T.; Sparrow, Doris A.; Fernando, Germain Biochemistry, Vol. 31, Issue 4, p. 1065-1068 https://doi.org/10.1021/bi00119a015	journal	February 1992
Methods and reagents for modulating cholesterol levels Hayden, Michael R.; Wilson, Angela R. Brooks; Pimstone, Simon N. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040058869 US Patent Application 10/617334; 20040058869	patent-application	March 2004
Helical synthetic peptides that stimulate cellular cholesterol efflux Bielicki, John K.; Natarajan, Pradeep https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050202532 US Patent Application 11/014187; 20050202532	patent-application	September 2005
Orally administered peptides synergize statin activity Fogelman, Alan M.; Anantharamaiah, Gattadahalli M.; Navab, Mohamad https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080096815 US Patent Application 11/830675; 20080096815	patent-application	April 2008
Compositions and methods of use for treating cardiovascular disease Heinecke, Jay W.; Oram, John F.; Oda, Michael N. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080234192 US Patent Application 11/952044; 20080234192	patent-application	September 2008

Similar Records

Peptide mediators of cholesterol efflux

Patent · Tue Apr 09 00:00:00 EDT 2013 · OSTI ID:1174197

Bielicki, John K.; Johansson, Jan

Peptides having reduced toxicity that stimulate cholesterol efflux

Patent · Tue Sep 15 00:00:00 EDT 2020 · OSTI ID:1174197

Bielicki, John K.; Johansson, Jan; Danho, Waleed

Peptides having reduced toxicity that stimulate cholesterol efflux

Patent · Tue Sep 06 00:00:00 EDT 2022 · OSTI ID:1174197

Bielicki, John K.; Johansson, Jan; Danho, Waleed

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Title: Potent and selective mediators of cholesterol efflux

Citation Formats

References (11)

Similar Records

Related Subjects