skip to main content

Title: Study of polymer molecules and conformations with a nanopore

The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
1171692
Report Number(s):
8,969,091
13/766,231
DOE Contract Number:
FG02-01ER45922
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Feb 13
Research Org:
President and Fellows of Harvard College, Cambridge, MA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE