Devices, systems, and methods for conducting sandwich assays using sedimentation

Schaff, Ulrich Y; Sommer, Gregory J; Singh, Anup K; Hatch, Anson V

Title: Devices, systems, and methods for conducting sandwich assays using sedimentation

Patent · Tue Feb 03 00:00:00 EST 2015

OSTI ID:1169095

Schaff, Ulrich Y; Sommer, Gregory J; Singh, Anup K; Hatch, Anson V

Embodiments of the present invention are directed toward devices, systems, and method for conducting sandwich assays using sedimentation. In one example, a method includes generating complexes on a plurality of beads in a fluid sample, individual ones of the complexes comprising a capture agent, a target analyte, and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Number(s):: 8,945,914

Application Number:: 12/891,977

OSTI ID:: 1169095

Country of Publication:: United States

Language:: English

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