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Title: Expanding the eukaryotic genetic code

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
1169093
Report Number(s):
8,945,926
13/329,202
DOE Contract Number:
FG0300ER45812
Resource Type:
Patent
Research Org:
The Scripps Research Institute, La Jolla, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES