Structure and inhibition of EV-D68, a virus that causes respiratory illness in children

Liu, Yue; Sheng, Ju; Fokine, Andrei; Meng, Geng; Shin, Woong-Hee; Long, Feng; Kuhn, Richard J.; Kihara, Daisuke; Rossmann, Michael G.

doi:10.1126/science.1261962

Title: Structure and inhibition of EV-D68, a virus that causes respiratory illness in children

Journal Article · Fri Jan 02 00:00:00 EST 2015 · Science

DOI:https://doi.org/10.1126/science.1261962· OSTI ID:1168487

Liu, Yue ^[1]; Sheng, Ju ^[1]; Fokine, Andrei ^[1]; Meng, Geng ^[1]; Shin, Woong-Hee ^[1]; Long, Feng ^[1]; Kuhn, Richard J. ^[1]; Kihara, Daisuke ^[2]; Rossmann, Michael G. ^[1]

Purdue Univ., West Lafayette, IN (United States). Hockmeyer Hall of Structural Biology. Dept. of Biological Sciences
Purdue Univ., West Lafayette, IN (United States). Hockmeyer Hall of Structural Biology. Dept. of Biological Sciences. Dept. of Computer Science

Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report in this paper the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. Finally, we also showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks.

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Research Organization:: Purdue Univ., West Lafayette, IN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Inst. of Health (NIH) (United States)

Grant/Contract Number:: AC02-06CH11357; RR007707; AI11219

OSTI ID:: 1168487

Journal Information:: Science, Vol. 347, Issue 6217; ISSN 0036-8075

Publisher:: AAASCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 111 works

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