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Title: Methods for engineering polypeptide variants via somatic hypermutation and polypeptide made thereby

Methods using somatic hypermutation (SHM) for producing polypeptide and nucleic acid variants, and nucleic acids encoding such polypeptide variants are disclosed. Such variants may have desired properties. Also disclosed are novel polypeptides, such as improved fluorescent proteins, produced by the novel methods, and nucleic acids, vectors, and host cells comprising such vectors.
Authors:
;
Publication Date:
OSTI Identifier:
1167214
Report Number(s):
8,932,859
12/124,888
DOE Contract Number:
FG03-01ER63276
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 May 21
Research Org:
The Regents of the University of California, Oakland, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES