Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations

Journal Article · Mon Dec 08 00:00:00 EST 2014 · Analytical Chemistry

DOI:https://doi.org/10.1021/ac503564c· OSTI ID:1165165

Chen, Tsung-Chi ^[1]; Webb, Ian K. ^[1]; Prost, Spencer A. ^[1]; Harrer, Marques B. ^[1]; Norheim, Randolph V. ^[1]; Tang, Keqi ^[1]; Ibrahim, Yehia M. ^[1]; Smith, Richard D. ^[1]

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1. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States

A recent achievement in Structures for Lossless Ion Manipulations (SLIM) is the ability for near lossless ion focusing, transfer, and trapping in sub-atmospheric pressure regions. While lossless ion manipulations are advantageously applied to the applications of ion mobility separations and gas phase reactions, ion introduction through ring electrode ion funnels or more conventional ion optics to SLIM can involve discontinuities in electric fields or other perturbations that result in ion losses. In this work, we investigated a new funnel design that aims to seamlessly couple to SLIM at the funnel exit. This rectangular ion funnel (RIF) was initially evaluated by ion simulations, fabricated utilizing printed circuit board technology and tested experimentally. The RIF was integrated to a SLIM-TOFMS system, and the operating parameters, including RF, DC bias of the RIF electrodes, and electric fields for effectively interfacing with a SLIM were characterized. The RIF provided a 2-fold sensitivity increase without significant discrimination over a wide m/z range along with greatly improved SLIM operational stability.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Biological and Environmental Research (BER)
• Grant/Contract Number: AC05-76RL01830; P41 GM103493
• OSTI ID: 1165165
• Alternate ID(s): OSTI ID: 1170044
• Report Number(s): PNNL-SA-105304
• Journal Information: Analytical Chemistry, Journal Name: Analytical Chemistry Vol. 87 Journal Issue: 1; ISSN 0003-2700
• Publisher: American Chemical Society
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Lossless Ion Manipulations
rectangular ion funnel (RIF)
Environmental Molecular Sciences Laboratory