Scalable Low-Cost Fabrication of Disposable Paper Sensors for DNA Detection

Gandhiraman, Ram P.; Nordlund, Dennis; Jayan, Vivek; Meyyappan, M.; Koehne, Jessica E.

doi:10.1021/am5069003

Title: Scalable Low-Cost Fabrication of Disposable Paper Sensors for DNA Detection

Journal Article · Fri Dec 05 00:00:00 EST 2014 · ACS Applied Materials and Interfaces

DOI:https://doi.org/10.1021/am5069003· OSTI ID:1165085

Gandhiraman, Ram P. ^[1]; Nordlund, Dennis ^[2]; Jayan, Vivek ^[1]; Meyyappan, M. ^[1]; Koehne, Jessica E. ^[1]

NASA Ames Research Center, Moffett Field, California 94035, United States
Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States

Controlled integration of features that enhance the analytical performance of a sensor chip is a challenging task in the development of paper sensors. A critical issue in the fabrication of low-cost biosensor chips is the activation of the device surface in a reliable and controllable manner compatible with large-scale production. Here, we report stable, well-adherent, and repeatable site-selective deposition of bioreactive amine functionalities and biorepellant polyethylene glycol-like (PEG) functionalities on paper sensors by aerosol-assisted, atmospheric-pressure, plasma-enhanced chemical vapor deposition. This approach requires only 20 s of deposition time, compared to previous reports on cellulose functionalization, which takes hours. We present a detailed analysis of the near-edge X-ray absorption fine structure (NEXAFS) and its sensitivity to the local electronic structure of the carbon and nitrogen functionalities. σ*, π*, and Rydberg transitions in C and N K-edges. Lastly, application of the plasma-processed paper sensors in DNA detection is also demonstrated.

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Research Organization:: SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Aeronautics and Space Administration (NASA); National Institutes of Health (NIH)

Grant/Contract Number:: AC02-76SF00515; P41GM103393

OSTI ID:: 1165085

Alternate ID(s):: OSTI ID: 1295338

Journal Information:: ACS Applied Materials and Interfaces, Journal Name: ACS Applied Materials and Interfaces Vol. 6 Journal Issue: 24; ISSN 1944-8244

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 15 works

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