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Title: Engineering of thermotolerant Bacillus coagulans for production of D(-)-lactic acid

Genetically modified microorganisms having the ability to produce D(-)-lactic acid at temperatures between 30.degree. C. and 55.degree. C. are provided. In various embodiments, the microorganisms may have the chromosomal lactate dehydrogenase (ldh) gene and/or the chromosomal acetolactate synthase (alsS) gene inactivated. Exemplary microorganisms for use in the disclosed methods are Bacillus spp., such as Bacillus coagulans.
Authors:
; ;
Publication Date:
OSTI Identifier:
1164688
Report Number(s):
8,900,835
13/301,836
DOE Contract Number:
FG36-04GO14019
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Nov 22
Research Org:
University of Florida Research Foundation, Inc., Gainesville, FL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 54 ENVIRONMENTAL SCIENCES