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Title: Subcellular analysis by laser ablation electrospray ionization mass spectrometry

In various embodiments, a method of laser ablation electrospray ionization mass spectrometry (LAESI-MS) may generally comprise micro-dissecting a cell comprising at least one of a cell wall and a cell membrane to expose at least one subcellular component therein, ablating the at least one subcellular component by an infrared laser pulse to form an ablation plume, intercepting the ablation plume by an electrospray plume to form ions, and detecting the ions by mass spectrometry.
Authors:
; ;
Publication Date:
OSTI Identifier:
1164685
Report Number(s):
8,901,487
13/045,277
DOE Contract Number:
FG02-01ER15129
Resource Type:
Patent
Research Org:
George Washington University, Washington, DC (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 47 OTHER INSTRUMENTATION