Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability

Nomme, Julian; Li, Zheng; Gipson, Raymond M.; Wang, Jue; Armijo, Amanda L.; Le, Thuc; Poddar, Soumya; Smith, Tony; Santarsiero, Bernard D.; Nguyen, Hien-Anh; Czernin, Johannes; Alexandrova, Anastassia N.; Jung, Michael E.; Radu, Caius G.; Lavie, Arnon

doi:10.1021/jm501124j

Title: Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability

Journal Article · Fri Nov 07 00:00:00 EST 2014 · Journal of Medicinal Chemistry

DOI:https://doi.org/10.1021/jm501124j· OSTI ID:1163572

Nomme, Julian ^[1]; Li, Zheng; Gipson, Raymond M.; Wang, Jue; Armijo, Amanda L.; Le, Thuc; Poddar, Soumya; Smith, Tony; Santarsiero, Bernard D.; Nguyen, Hien-Anh ^[1]; Czernin, Johannes; Alexandrova, Anastassia N.; Jung, Michael E.; Radu, Caius G.; Lavie, Arnon ^[1]

Department of Biochemistry and Molecular Genetics, and ‡Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, Illinois 60607, United States

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02- 06CH11357

OSTI ID:: 1163572

Journal Information:: Journal of Medicinal Chemistry, Journal Name: Journal of Medicinal Chemistry Vol. 57 Journal Issue: 22; ISSN 0022-2623

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 13 works

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References (30)

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