Mechanisms of Resistance Can Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of beta-Lactam¿beta-Lactamase Inhibitor Combinations

Journal Article · Sun Dec 01 00:00:00 EST 2013 · Antimicrobial Agents and Chemotherapy

DOI:https://doi.org/10.1128/AAC.01253-13· OSTI ID:1162720

Kurz, S.; Wolff, K.; Hazra, S.; Bethel, C.; Hujer, A.; Smith, K.; Xu, Y.; Tremblay, L.; Blanchard, J.

• Research Organization: Brookhaven National Lab. (BNL), Upton, NY (United States)
• Sponsoring Organization: USDOE SC OFFICE OF SCIENCE (SC)
• DOE Contract Number: DE-AC02-98CH10886
• OSTI ID: 1162720
• Report Number(s): BNL-106666-2014-JA
• Journal Information: Antimicrobial Agents and Chemotherapy, Vol. 57, Issue 12; ISSN 0066--4804
• Country of Publication: United States
• Language: English