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Title: Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease

Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with .sup.18F, .sup.123I, or .sup.124I, or free hexoses radiolabeled with .sup.18F, .sup.123I, or .sup.124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
1160128
Report Number(s):
8,845,999
11/920,904
DOE Contract Number:
FC03-02ER63420
Resource Type:
Patent
Resource Relation:
Patent File Date: 2006 May 23
Research Org:
University of California, Oakland, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES