Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors

Journal Article · Tue Apr 29 00:00:00 EDT 2014 · ACS CHEMICAL NEUROSCIENCE

DOI:https://doi.org/10.1021/cn500021p· OSTI ID:1160043

Fowler, J.; Seo, Y. J.; Kang, Y.; Muench, L.; Reid, A.; Caesar, S.; Logan, J.; Wagner, F.; Holson, E.; Haggarty, S. J.; Weiss, P.; King, P.; Carter, P.; Volkow, N. D.; Fowler, J. S.; Hooker, J. M.; Kim, S. W.

• Research Organization: Brookhaven National Lab. (BNL), Upton, NY (United States). Positron Emission Tomography (PET) Facility
• Sponsoring Organization: USDOE SC OFFICE OF BIOLOGICAL & ENVIRONMENTAL RESEARCH
• DOE Contract Number: DE-AC02-98CH10886
• OSTI ID: 1160043
• Report Number(s): BNL-106124-2014-JA; R&D Project: MO-085; KP1602010
• Journal Information: ACS CHEMICAL NEUROSCIENCE, Vol. 5
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
histone acetylase
PET (positron emission tomography)
BBB (blood-brain barrier)
CNS (central nervous system)
C11 (carbon-11)
brain diseases
blood-brain barrier permeability
benzamides
HDAC (histone deacetylase)
positron emission tomography (PET) facility