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Title: Fermentation process using specific oxygen uptake rates as a process control

Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
Authors:
; ;
Publication Date:
OSTI Identifier:
1157563
Report Number(s):
8,828,707
13/078,128
DOE Contract Number:
FC36-00GO10598
Resource Type:
Patent
Research Org:
Cargill Incorporated, Wayzata, MN (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES