Engineering the Interface Between Inorganic Materials and Cells
To further optimize cell function in hybrid “living materials”, it would be advantageous to render mammalian cells responsive to novel “orthogonal” cues, i.e. signals they would not ordinarily respond to but that can be engineered to feed into defined intracellular signaling pathways. We recently developed an optogenetic method, based on A. thaliana Cry2, for rapid and reversible protein oligomerization in response to blue light. We also demonstrated the ability to use this method to channel the light input into several defined signaling pathways, work that will enhance communication between inorganic devices and living systems.
- Publication Date:
- OSTI Identifier:
- Report Number(s):
- DOE Contract Number:
- Resource Type:
- Technical Report
- Research Org:
- University of California, Berkeley
- Sponsoring Org:
- USDOE; USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
- Country of Publication:
- United States
- 36 MATERIALS SCIENCE materials engineering, cell-material interface, light, optogenetics
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