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Title: Methods for threshold determination in multiplexed assays

Methods for determination of threshold values of signatures comprised in an assay are described. Each signature enables detection of a target. The methods determine a probability density function of negative samples and a corresponding false positive rate curve. A false positive criterion is established and a threshold for that signature is determined as a point at which the false positive rate curve intersects the false positive criterion. A method for quantitative analysis and interpretation of assay results together with a method for determination of a desired limit of detection of a signature in an assay are also described.
Authors:
; ;
Publication Date:
OSTI Identifier:
1134715
Report Number(s):
8,672,068
12/607,956
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Patent
Research Org:
University of California (USA)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION