Improving Ion Mobility Measurement Sensitivity by Utilizing Helium in an Ion Funnel-Trap
Ion mobility instruments that utilize nitrogen as buffer gas are often preceded by an ion trap and accumulation region that also uses nitrogen, and for different inert gases no significant effects upon performance are expected for IMS of larger ions. However, we have observed significantly improved performance for an ion funnel trap upon adding helium; the signal intensities for higher m/z species were improved by more than an order of magnitude compared to using pure nitrogen. The effect of helium upon IMS resolving power was also studied by introducing a He/N2 gas mixture into the drift cell, and in some cases a slight improvement was observed compared to pure N2. The improvement in signal can be largely attributed to faster and more efficient ion ejection into the drift tube from the ion funnel trap.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1133216
- Report Number(s):
- PNNL-SA-100190; 48135; 400412000
- Journal Information:
- Analytical Chemistry, 86(11):5295-5299, Journal Name: Analytical Chemistry, 86(11):5295-5299
- Country of Publication:
- United States
- Language:
- English
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