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Title: Methods for targetted mutagenesis in gram-positive bacteria

The present invention provides a method of targeted mutagenesis in Gram-positive bacteria. In particular, the present invention provides a method that effectively integrates a suicide integrative vector into a target gene in the chromosome of a Gram-positive bacterium, resulting in inactivation of the target gene.
Authors:
Publication Date:
OSTI Identifier:
1132802
Report Number(s):
8,735,160
12/233,806
DOE Contract Number:
AC05-000R22725
Resource Type:
Patent
Research Org:
ORNL (Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States))
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES