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Title: Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1

Abstract

It has been identified in accordance with the present invention that Nell1 is essential for normal cardiovascular development by promoting proper formation of the heart and blood vessels. The present invention therefore provides therapeutic methods for treating cardiovascular disorders by employing a Nell1 protein or nucleic acid molecule.

Inventors:
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1131020
Patent Number(s):
8,722,625
Application Number:
12/284,667
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
DOE Contract Number:  
AC05-000R22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Culiat, Cymbeline T. Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1. United States: N. p., 2014. Web.
Culiat, Cymbeline T. Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1. United States.
Culiat, Cymbeline T. 2014. "Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1". United States. https://www.osti.gov/servlets/purl/1131020.
@article{osti_1131020,
title = {Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1},
author = {Culiat, Cymbeline T},
abstractNote = {It has been identified in accordance with the present invention that Nell1 is essential for normal cardiovascular development by promoting proper formation of the heart and blood vessels. The present invention therefore provides therapeutic methods for treating cardiovascular disorders by employing a Nell1 protein or nucleic acid molecule.},
doi = {},
url = {https://www.osti.gov/biblio/1131020}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 13 00:00:00 EDT 2014},
month = {Tue May 13 00:00:00 EDT 2014}
}

Works referenced in this record:

Nell peptide expression systems and bone formation activity of nell peptide
patent-application, December 2006


Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects
journal, March 2006


Method to Treat or Prevent a Skin Condition Using a Nell 1 Peptide
patent-application, September 2011


Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats
journal, December 1996


Cell-Based Approaches for Cardiac Repair
journal, October 2006


Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts
journal, March 2007


The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)
journal, June 2004

  • Tsutsumi, Satoshi; Kamata, Nobuyuki; Vokes, Tamara J.
  • The American Journal of Human Genetics, Vol. 74, Issue 6, p. 1255-1261
  • https://doi.org/10.1086/421527

Nfatc2 is a primary response gene of nell-1 regulating chondrogenesis in ATDC5 cells
journal, May 2011


Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
journal, January 2001


Bone marrow cells for cardiac regeneration and repair: current status and issues
journal, July 2006


The osteoinductive properties of Nell-1 in a rat spinal fusion model
journal, January 2007


Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
journal, August 2007


Effect of Nell-1 Delivery on Chondrocyte Proliferation and Cartilaginous Extracellular Matrix Deposition
journal, May 2010


Composition for cartilage
patent-application, June 2007


Nell-1 induced bone formation within the distracted intermaxillary suture
journal, January 2006


Nell-1 enhanced bone mineralization
patent-application, May 2006


Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development
journal, May 2006


Cranial and vertebral defects associated with loss-of-function of Nell
patent-application, March 2006


A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation
journal, October 2007


Human NELL-1 Expressed in Unilateral Coronal Synostosis
journal, January 1999


NELL-1 enhanced bone mineralization
patent-application, October 2006


Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2
journal, November 1999


From cardiac repair to cardiac regeneration – ready to translate?
journal, August 2006


Growth Factor Enhancement of Cardiac Regeneration
journal, January 2006


Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C
journal, November 1999


Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
journal, December 2003


Adenovirus vectors encoding brain natriuretic peptide
patent-application, February 2006


Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
journal, June 2001


Nell-1-Induced Bone Regeneration in Calvarial Defects
journal, September 2006