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Title: DE-SC0002437 Final Report

We developed a SPECT/CT system for small-animal imaging utilizing a mechanically cooled, position-sensitive germanium detector for the SPECT camera. The detector offers better energy resolution than any other detector previously used for SPECT and demonstrates dual-isotope imaging capabilities superior to that of current commercial small-animal SPECT systems. We also explored a unique SPECT camera configuration consisting of a silicon detector and germanium detector stacked one behind the other and located behind a multi-pinhole collimator. This scheme is intended for imaging iodine-123 radiotracer distributions, with the ~30 keV x-ray emissions detected in the silicon detector and the 159 keV gamma-ray emissions passing through the silicon and detected in the germanium detector. Image reconstruction methods for combining this multi-energy, multi-magnification data were developed and it was shown that inclusion of the silicon data reduced artifacts in comparison to the germanium data alone.
  1. Vanderbilt University
Publication Date:
OSTI Identifier:
Report Number(s):
DOE Contract Number:
Resource Type:
Technical Report
Research Org:
Vanderbilt University
Sponsoring Org:
USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
Contributing Orgs:
Vanderbilt University
Country of Publication:
United States
62 RADIOLOGY AND NUCLEAR MEDICINE radiation detectors, SPECT, preclinical imaging