U.S. Department of EnergyOffice of Scientific and Technical Information
Arterial endothelial function measurement method and apparatus
Abstract
A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.
- Inventors:
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1126883
- Patent Number(s):
- 8,666,472
- Application Number:
- 11/362,326
- Assignee:
- The Regents of the University of California (Oakland, CA)
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Maltz, Jonathan S, and Budinger, Thomas F. Arterial endothelial function measurement method and apparatus. United States: N. p., 2014.
Web.
Maltz, Jonathan S, & Budinger, Thomas F. Arterial endothelial function measurement method and apparatus. United States.
Maltz, Jonathan S, and Budinger, Thomas F. 2014.
"Arterial endothelial function measurement method and apparatus". United States. https://www.osti.gov/servlets/purl/1126883.
@article{osti_1126883,
title = {Arterial endothelial function measurement method and apparatus},
author = {Maltz, Jonathan S and Budinger, Thomas F},
abstractNote = {A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.},
doi = {},
url = {https://www.osti.gov/biblio/1126883},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 04 00:00:00 EST 2014},
month = {Tue Mar 04 00:00:00 EST 2014}
}
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Works referencing / citing this record:
Arterial endothelial function measurement method and apparatus
patent, March 2014
- Maltz, Jonathan; Budinger, Thomas
- US Patent Document 8,666,472