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Title: Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells

This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
Authors:
; ;
Publication Date:
OSTI Identifier:
1126420
Report Number(s):
8,658,395
13/546,582
DOE Contract Number:
FG03-00ER45812
Resource Type:
Patent
Research Org:
The Scripps Research Institute, La Jolla, CA, USA
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES